The multifaceted functions of CXCL10 in cardiovascular disease.
The multifaceted functions of CXCL10 in cardiovascular disease.
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DOI：
10.1155/2014/893106
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发表时间：
2014
影响因子：
--
通讯作者：
Pasterkamp G
中科院分区：
文献类型：
--
作者：
van den Borne P;Quax PH;Hoefer IE;Pasterkamp G
C-X-C基序配体10(CXCL10)，或干扰素诱导蛋白-10，是属于CXC趋化因子家族的一种小分子趋化因子。它的成员负责白细胞的运输，并作用于组织细胞，如内皮细胞和血管平滑肌细胞。CXCL10由白细胞和组织细胞分泌，具有趋化作用，主要作用于淋巴细胞。CXCL10与其受体CXCR3结合后，可引起一系列炎症反应：心血管疾病(CVD)的关键特征。CXCL10在心血管疾病中的作用已被广泛描述，例如在动脉粥样硬化、动脉瘤形成和心肌梗死中。然而，在实验和临床设置之间似乎存在差异。这种差异是由于物种(例如小鼠和人类)之间的生物学作用的差异，这依赖于CXCL10信号通过不同的CXCR3亚型或不依赖于CXCR3的信号。这使得从实验环境到临床环境的转换具有挑战性。此外，关于CXCL10在具体的心血管疾病模型中的作用的总体共识尚未达成。这篇综述的目的是描述CXCL10在实验和临床环境中不同心血管疾病中的功能，并强调和讨论可能的差异和翻译困难。此外，还将讨论CXCL10作为CVD的一个可能的生物标志物。
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family. Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells. CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for lymphocytes. After binding to its receptor CXCR3, CXCL10 evokes a range of inflammatory responses: key features in cardiovascular disease (CVD). The role of CXCL10 in CVD has been extensively described, for example for atherosclerosis, aneurysm formation, and myocardial infarction. However, there seems to be a discrepancy between experimental and clinical settings. This discrepancy occurs from differences in biological actions between species (e.g. mice and human), which is dependent on CXCL10 signaling via different CXCR3 isoforms or CXCR3-independent signaling. This makes translation from experimental to clinical settings challenging. Furthermore, the overall consensus on the actions of CXCL10 in specific CVD models is not yet reached. The purpose of this review is to describe the functions of CXCL10 in different CVDs in both experimental and clinical settings and to highlight and discuss the possible discrepancies and translational difficulties. Furthermore, CXCL10 as a possible biomarker in CVD will be discussed.
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影响因子：
3.7
作者：
Campanella GS;Colvin RA;Luster AD
通讯作者：
Luster AD
影响因子：
4.6
作者：
Ardigo, Diego;Assimes, Themistocles L.;Quertermous, Thomas
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3.5
作者：
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影响因子：
20.1
作者：
Bodnar, RJ;Yates, CC;Wells, A
通讯作者：
Wells, A
影响因子：
20.1
作者：
Bujak M;Dobaczewski M;Gonzalez-Quesada C;Xia Y;Leucker T;Zymek P;Veeranna V;Tager AM;Luster AD;Frangogiannis NG
通讯作者：
Frangogiannis NG