Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population.
Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population.
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DOI：
10.1186/s12967-015-0459-3
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发表时间：
2015-04-13
影响因子：
7.4
通讯作者：
Chouchane L
中科院分区：
文献类型：
--
作者：
Tomei S;Mamtani R;Al Ali R;Elkum N;Abdulmalik M;Ismail A;Cheema S;Rouh HA;Aigha II;Hani F;Al-Samraye S;Taher Aseel M;El Emadi N;Al Mujalli A;Abdelkerim A;Youssif S;Worschech A;El Sebakhy E;Temanni R;Khanna V;Wang E;Kizhakayil D;Al-Thani AA;Al-Thani M;Lowenfels A;Marincola FM;Sheikh J;Chouchane L
在卡塔尔，人口规模小，血缘关系比率高，三分之二到四分之三的成年人超重或肥胖。我们调查了卡塔尔人群中与肥胖相关的23个基因座的相关性。804名被评估为第三代卡塔尔人的人被纳入研究，并根据他们的身体质量指数分为3组：190瘦(BMI <； 25g/m2)；131超重(≤BMI <； 30g/m2)和483肥胖(BMI ≥ 30g/m2)。从外周血中提取基因组DNA，TaqMan进行基因分型。与卡塔尔人肥胖显著相关的两个基因座：TFAP2B变异(Rs987237)(A等位基因对G等位基因：卡方 = 10.3；P = 0.0013)和GNPDA2变异(Rs10938397)(A等位基因对G等位基因：卡方 = 6.15；P = 0.013)。TFAP2BGG基因与肥胖呈负相关(OR = 为0.21；P = 为0.0031)。相反，在 <； 32岁的受试者中，GNDPA2GG纯合子基因与肥胖风险增加相关(P = 0.0358)。与西方人群相比，我们在卡塔尔人群中显示了与肥胖相关的不同基因图谱。研究卡塔尔人的遗传背景是最重要的，因为特定疾病的病因可能是特定于人群的。本文的在线版本(doi：10.1186/s12967-0150459-3)包含补充材料，授权用户可以使用。
In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m2); 131 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) and 483 obese (BMI ≥ 30 kg/m2). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific. The online version of this article (doi:10.1186/s12967-015-0459-3) contains supplementary material, which is available to authorized users.
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影响因子：
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作者：
Mejía-Benítez A;Klünder-Klünder M;Yengo L;Meyre D;Aradillas C;Cruz E;Pérez-Luque E;Malacara JM;Garay ME;Peralta-Romero J;Flores-Huerta S;García-Mena J;Froguel P;Cruz M;Bonnefond A
通讯作者：
Bonnefond A
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
40.5
作者：
Loos, Ruth J. F.;Yeo, Giles S. H.
通讯作者：
Yeo, Giles S. H.
影响因子：
30.8
作者：
通讯作者：
--
影响因子：
5.8
作者：
Cheung, Chloe Y. Y.;Tso, Annette W. K.;Lam, Karen S. L.
通讯作者：
Lam, Karen S. L.