Biological Function of MicroRNA193a-3p in Health and Disease.
Biological Function of MicroRNA193a-3p in Health and Disease.
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DOI：
10.1155/2017/5913195
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发表时间：
2017
影响因子：
2.9
通讯作者：
De Petro G
中科院分区：
文献类型：
--
作者：
Grossi I;Salvi A;Abeni E;Marchina E;De Petro G
MicroRNAs(MiRNAs)是一类小的非编码RNA，主要作为基因表达的负调控因子。一些研究表明，miRNAs参与了许多生物学过程，如增殖、凋亡和迁移。MiRNAs的失调在包括癌症在内的不同类型的疾病中经常被观察到。在这里，我们通过考虑其在生理和病理背景下的作用，对人类miR-193a-3p进行了全面的综述。已有报道涉及调节miR-193a-3p表达的不同机制，包括表观遗传修饰和转录因子。在生理环境中，miR-193a-3p似乎能够限制正常细胞的增殖和细胞周期进展。值得注意的是，一些文献表明miR-193a-3p通过靶向参与增殖、凋亡、迁移、侵袭和转移的不同基因，在癌症中发挥肿瘤抑制因子的作用。此外，在许多原发肿瘤中观察到miR-193a-3p的下调，并在癌症患者和帕金森病或精神分裂症患者的血清或血浆中发现循环miR-193a-3p水平的变化。从临床的角度来看，还需要进一步的研究来探索miR-193a-3p模拟载体的抗肿瘤作用，以及这种miRNA检测作为可能的诊断和预后生物标记物的相关性。
MicroRNAs (miRNAs) are a class of small noncoding RNAs that act mainly as negative regulators of gene expression. Several studies demonstrated that miRNAs take part in numerous biological processes, such as proliferation, apoptosis, and migration. The dysregulation of miRNAs has been frequently observed in different types of disease, including cancer. Here, we provide a comprehensive review on the human miR-193a-3p by considering its role in both physiological and pathological contexts. Different mechanisms involved in regulating miR-193a-3p expression have been reported, including epigenetic modifications and transcription factors. In physiological contexts, miR-193a-3p seemed able to limit proliferation and cell cycle progression in normal cells. Remarkably, several publications demonstrated that miR-193a-3p acted as a tumor suppressor miRNA in cancer by targeting different genes involved in proliferation, apoptosis, migration, invasion, and metastasis. Furthermore, the downregulation of miR-193a-3p has been observed in many primary tumors and altered levels of circulating miR-193a-3p have been identified in serum or plasma of cancer patients and subjects affected by Parkinson's disease or by schizophrenia. In a clinical perspective, further studies are needed to explore the antitumor effects of the miR-193a-3p mimics delivery and the relevance of this miRNA detection as a possible diagnostic and prognostic biomarker.
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影响因子：
--
作者：
Grossi I;Arici B;Portolani N;De Petro G;Salvi A
通讯作者：
Salvi A
影响因子：
11.2
作者：
Kozaki, Ken-ichi;Imoto, Issei;Inazawa, Johji
通讯作者：
Inazawa, Johji
miR-193a-3p通过靶向LOXL4基因和氧化应激途径调节膀胱癌的多药耐药性。
影响因子：
37.3
作者：
Deng H;Lv L;Li Y;Zhang C;Meng F;Pu Y;Xiao J;Qian L;Zhao W;Liu Q;Zhang D;Wang Y;Zhang H;He Y;Zhu J
通讯作者：
Zhu J
影响因子：
3.7
作者：
Gilad S;Meiri E;Yogev Y;Benjamin S;Lebanony D;Yerushalmi N;Benjamin H;Kushnir M;Cholakh H;Melamed N;Bentwich Z;Hod M;Goren Y;Chajut A
通讯作者：
Chajut A
影响因子：
4.8
作者：
Dai, Xin;Chen, Xi;Xia, Lu
通讯作者：
Xia, Lu