Parasitic infections: a role for C-type lectins receptors.

Parasitic infections: a role for C-type lectins receptors.
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DOI:
10.1155/2013/456352
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发表时间:
2013
影响因子:
--
通讯作者:
Rodriguez-Sosa M
Rodriguez-Sosa M
中科院分区:
生物学3区
文献类型:
--
作者:
Vázquez-Mendoza A;Carrero JC;Rodriguez-Sosa M

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抗原呈递细胞(APC)通过识别病原体相关分子模式的几种类型的受体来感知微环境。特别地,由树突状细胞(DC)和巨噬细胞(巨噬细胞)的不同亚群表达的C型凝集素受体(CLR)以Ca 2+依赖性方式识别并内化特定的碳水化合物抗原。靶向这些受体正成为寄生虫识别的有效策略。然而,人们对TLR如何参与病原体识别和寄生虫内化的了解相对较少。CLRs在寄生虫感染中的作用是一个相当感兴趣的领域,因为这项研究将影响我们对先天免疫应答启动的理解,先天免疫应答会影响特异性免疫应答的结果。本文试图总结我们对寄生虫与CLRs相互作用的认识。
Antigen-presenting cells (APCs) sense the microenvironment through several types of receptors that recognize pathogen-associated molecular patterns. In particular, C-type lectins receptors (CLRs), which are expressed by distinct subsets of dendritic cells (DCs) and macrophages (MØs), recognize and internalize specific carbohydrate antigens in a Ca2+-dependent manner. The targeting of these receptors is becoming an efficient strategy for parasite recognition. However, relatively little is known about how CLRs are involved in both pathogen recognition and the internalization of parasites. The role of CLRs in parasite infections is an area of considerable interest because this research will impact our understanding of the initiation of innate immune responses, which influences the outcome of specific immune responses. This paper attempts to summarize our understanding of the effects of parasites' interactions with CLRs.
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