Relationship between Alzheimer's disease GWAS-linked top hits and risk of Parkinson's disease with or without cognitive decline: a Chinese population-based study
Relationship between Alzheimer's disease GWAS-linked top hits and risk of Parkinson's disease with or without cognitive decline: a Chinese population-based study
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阿尔茨海默病 GWAS 相关的热门热门与有或没有认知能力下降的帕金森病风险之间的关系：一项基于中国人群的研究
DOI：
10.1016/j.neurobiolaging.2015.11.024
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发表时间：
2016-03
影响因子：
4.2
通讯作者：
Guo Ji feng
中科院分区：
文献类型：
--
作者：
Wang Ya qin;Tang Bei sha;Yang Yang;Cui Yi ting;Kang Ji feng;Liu Zhen hua;Li Kai;Sun Qi ying;Xu Qian;Yan Xin xiang;Guo Ji feng
阿尔茨海默病（AD）、帕金森病（PD）和PD中的认知损害具有重叠的临床和病理特征。为了验证这些疾病是否存在遗传联系，我们在中国人群中进行了一项病例对照研究，以评估AD全基因组关联研究的最高命中与PD和PD认知功能的关联，研究了9个基因（BIN 1，CLU，ABCA 7，CR 1，PICALM，MS 4A 6A，CD 33，MS 4A 4 E和CD 2AP）的13个单核苷酸多态性。共有454名对照和442名PD患者进行了基因分型，其中包括75名轻度认知障碍和99名痴呆。因此，在PD病例、PD-痴呆或PD-轻度认知障碍中，AD易感基因位点没有显著相关性。提示AD全基因组关联研究中发现的13个单核苷酸多态性在中国人群PD的遗传易感性和认知功能中可能不起主要作用。
Alzheimer's disease (AD), Parkinson's disease (PD), and cognitive impairment in PD have overlapping clinical and pathological features. To examine whether there is a genetic link for these diseases, we performed a case-control study in Chinese population to evaluate the association of AD genome-wide association studies top hits with both PD and cognitive function in PD, investigating 13 single-nucleotide polymorphisms in 9 genes (BIN1,CLU,ABCA7,CR1,PICALM,MS4A6A, CD33,MS4A4E, andCD2AP). A total of 454 controls and 442 PD patients were genotyped, including 75 mild cognitive impairment and 99 dementia. As a result, no significant association of the AD-susceptibility loci was identified in PD cases, PD–dementia, or PD–mild cognitive impairment. Our findings imply that the 13 single-nucleotide polymorphisms from AD genome-wide association studies may not play major role in the genetic predisposition with PD and cognitive function in PD in a Chinese population.
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DOI：
10.1073/pnas.98.2.581
发表时间：
2001-01
影响因子：
11.1
作者：
K. Buetow;Michael Edmonson;Richard Macdonald;R. Clifford;P. Yip;J. M. Kelley;D. Little;R. Strausberg-R
通讯作者：
K. Buetow;Michael Edmonson;Richard Macdonald;R. Clifford;P. Yip;J. M. Kelley;D. Little;R. Strausberg-R
影响因子：
3.7
作者：
Gao J;Huang X;Park Y;Hollenbeck A;Chen H
通讯作者：
Chen H
影响因子：
30.8
作者：
Harold, Denise;Abraham, Richard;Hollingworth, Paul;Sims, Rebecca;Gerrish, Amy;Hamshere, Marian L.;Pahwa, Jaspreet Singh;Moskvina, Valentina;Dowzell, Kimberley;Williams, Amy;Jones, Nicola;Thomas, Charlene;Stretton, Alexandra;Morgan, Angharad R.;Lovestone, Simon;Powell, John;Proitsi, Petroula;Lupton, Michelle K.;Brayne, Carol;Rubinsztein, David C.;Gill, Michael;Lawlor, Brian;Lynch, Aoibhinn;Morgan, Kevin;Brown, Kristelle S.;Passmore, Peter A.;Craig, David;McGuinness, Bernadette;Todd, Stephen;Holmes, Clive;Mann, David;Smith, A. David;Love, Seth;Kehoe, Patrick G.;Hardy, John;Mead, Simon;Fox, Nick;Rossor, Martin;Collinge, John;Maier, Wolfgang;Jessen, Frank;Schuermann, Britta;van den Bussche, Hendrik;Heuser, Isabella;Kornhuber, Johannes;Wiltfang, Jens;Dichgans, Martin;Froelich, Lutz;Hampel, Harald;Huell, Michael;Rujescu, Dan;Goate, Alison M.;Kauwe, John S. K.;Cruchaga, Carlos;Nowotny, Petra;Morris, John C.;Mayo, Kevin;Sleegers, Kristel;Bettens, Karolien;Engelborghs, Sebastiaan;De Deyn, Peter P.;Van Broeckhoven, Christine;Livingston, Gill;Bass, Nicholas J.;Gurling, Hugh;McQuillin, Andrew;Gwilliam, Rhian;Deloukas, Panagiotis;Al-Chalabi, Ammar;Shaw, Christopher E.;Tsolaki, Magda;Singleton, Andrew B.;Guerreiro, Rita;Muehleisen, Thomas W.;Noethen, Markus M.;Moebus, Susanne;Joeckel, Karl-Heinz;Klopp, Norman;Wichmann, H-Erich;Carrasquillo, Minerva M.;Pankratz, V. Shane;Younkin, Steven G.;Holmans, Peter A.;O'Donovan, Michael;Owen, Michael J.;Williams, Julie
通讯作者：
Williams, Julie
影响因子：
2
作者：
Ya-qin Wang;B. Tang;Xinxiang Yan;Zhiheng Chen;Qian Xu;Zhenhua Liu;Kai Li;Kai Wang;Ji-feng Guo
通讯作者：
Ya-qin Wang;B. Tang;Xinxiang Yan;Zhiheng Chen;Qian Xu;Zhenhua Liu;Kai Li;Kai Wang;Ji-feng Guo
影响因子：
--
作者：
Rocca, Walter A.;Bower, James H.;Maraganore, Demetrius M.
通讯作者：
Maraganore, Demetrius M.