Foot muscle energy reserves in diabetic patients without and with clinical peripheral neuropathy.
Foot muscle energy reserves in diabetic patients without and with clinical peripheral neuropathy.
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DOI：
10.2337/dc09-0536
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发表时间：
2009-08
期刊：
影响因子：
16.2
通讯作者：
Veves A
中科院分区：
文献类型：
--
作者：
Dinh T;Doupis J;Lyons TE;Kuchibhotla S;Julliard W;Gnardellis C;Rosenblum BI;Wang X;Giurini JM;Greenman RL;Veves A
研究糖尿病非神经病变和神经病变患者足部肌肉能量储备的变化。我们测量了磷酸肌酸酐（PCr）/无机磷酸盐（Pi）的比例，总31 P浓度，并在跖骨头区域的肌肉中使用MRI光谱在健康对照组和非神经性和神经性糖尿病患者的脂质/水比。PCr/Pi比值在对照组（3.23 ± 0.43）高于非神经病组（2.61 ± 0.36），而在神经病组最低（0.60 ± 1.02）（P < 0.0001）。对照组和非神经病组之间的总31 P浓度和脂/水比无差异，但神经病组的这两个测量值有差异（P < 0.0001）。静息足肌能量储备在糖尿病周围神经病变发生之前就受到影响，并与内皮功能障碍和炎症有关。
To investigate changes in the foot muscle energy reserves in diabetic non-neuropathic and neuropathic patients. We measured the phosphocreatinine (PCr)/inorganic phosphate (Pi) ratio, total 31P concentration, and the lipid/water ratio in the muscles in the metatarsal head region using MRI spectroscopy in healthy control subjects and non-neuropathic and neuropathic diabetic patients. The PCr/Pi ratio was higher in the control subjects (3.23 ± 0.43) followed by the non-neuropathic group (2.61 ± 0.36), whereas it was lowest in the neuropathic group (0.60 ± 1.02) (P < 0.0001). There were no differences in total 31P concentration and lipid/water ratio between the control and non-neuropathic groups, but both measurements were different in the neuropathic group (P < 0.0001). Resting foot muscle energy reserves are affected before the development of peripheral diabetic neuropathy and are associated with the endothelial dysfunction and inflammation.
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影响因子：
7.7
作者：
Caballero, AE;Arora, S;Veves, A
通讯作者：
Veves, A
影响因子：
16.2
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Pham, H;Harkless, LB;Veves, A
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168.9
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影响因子：
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作者：
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通讯作者：
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