Clinical and Immunological Effects of p53-Targeting Vaccines.
Clinical and Immunological Effects of p53-Targeting Vaccines.
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DOI：
10.3389/fcell.2021.762796
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发表时间：
2021
影响因子：
5.5
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Zhou S;Fan C;Zeng Z;Young KH;Li Y
免疫治疗，包括免疫检查点阻断和嵌合抗原受体T细胞，是治疗癌症最有前途的方法之一。疫苗在预防肝癌和宫颈癌等具有病毒病因的癌症方面是有效的。治疗性癌症疫苗不是预防疾病，而是动员免疫系统攻击现有的癌症。p53在大多数人类癌症中失调，并且是癌症疫苗的非常有希望的靶点。超过20项临床试验已经使用疫苗靶向恶性疾病中的p53。本文综述了以p53或其多肽为抗原的疫苗研究进展，并从临床试验中总结了以p53为靶点的疫苗的临床和免疫效果。递送平台包括p53肽、病毒载体和用短肽脉冲或由p53编码病毒转导的树突状细胞。这些研究揭示了p53疫苗在选定患者群体中的可行性、安全性和临床益处，暗示p53靶向疫苗需要在实验动物和人体研究中进行进一步研究。
Immunotherapy, including immune checkpoint blockade and chimeric antigen receptor T cells, is one of the most promising approaches to treat cancer. Vaccines have been effective in preventing cancers like liver cancer and cervical cancer with a viral etiology. Instead of preventing disease, therapeutic cancer vaccines mobilize the immune system to attack existing cancer. p53 is dysregulated in the majority of human cancers and is a highly promising target for cancer vaccines. Over twenty clinical trials have targeted p53 in malignant diseases using vaccines. In this work, we review the progress of vaccinations with p53 or its peptides as the antigens and summarize the clinical and immunological effects of p53-targeting vaccines from clinical trials. The delivery platforms include p53 peptides, viral vectors, and dendritic cells pulsed with short peptides or transduced by p53-encoding viruses. These studies shed light on the feasibility, safety, and clinical benefit of p53 vaccination in select groups of patients, implicating that p53-targeting vaccines warrant further investigations in experimental animals and human studies.
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DOI：
10.1007/s12094-018-1932-2
发表时间：
2019-03
期刊：
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
影响因子：
--
作者：
Chung V;Kos FJ;Hardwick N;Yuan Y;Chao J;Li D;Waisman J;Li M;Zurcher K;Frankel P;Diamond DJ
通讯作者：
Diamond DJ
DOI：
10.1158/1078-0432.ccr-17-2709
发表时间：
2018-03-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Hardwick NR;Frankel P;Ruel C;Kilpatrick J;Tsai W;Kos F;Kaltcheva T;Leong L;Morgan R;Chung V;Tinsley R;Eng M;Wilczynski S;Ellenhorn JDI;Diamond DJ;Cristea M
通讯作者：
Cristea M
影响因子：
5.8
作者：
Ellebaek, Eva;Engell-Noerregaard, Lotte;Svane, Inge Marie
通讯作者：
Svane, Inge Marie
影响因子：
5.4
作者：
HOUBIERS, JGA;NIJMAN, HW;MELIEF, CJM
通讯作者：
MELIEF, CJM
影响因子：
32.4
作者：
Hegde S;Leader AM;Merad M
通讯作者：
Merad M