Non-melanoma skin cancer occurring in patients treated with PUVA five to ten years after first treatment.
Non-melanoma skin cancer occurring in patients treated with PUVA five to ten years after first treatment.
复制标题
在首次治疗后五到十年接受 PUVA 治疗的患者中发生非黑色素瘤皮肤癌。
DOI：
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发表时间：
1988
影响因子：
6.5
通讯作者：
R. Lange
中科院分区：
文献类型：
--
作者：
R. Stern;R. Lange
对首次暴露于PUVA后10年入组PUVA研究的1，380名患者进行的持续前瞻性研究表明，PUVA累积暴露与皮肤鳞状细胞癌风险增加之间存在强相关性。对于首次治疗后至少58个月发生的肿瘤，在调整年龄，性别和居住地区后，我们观察到，与在相同时间间隔内接受160次或更少治疗的患者相比，接受260次以上治疗的患者风险增加11倍（P <0.01）。在所有皮肤类型的患者中观察到相对风险的可比增加，而不管先前的电离辐射暴露如何。我们还注意到，与同期接受少于160次治疗的患者相比，接受超过200次治疗的患者发生基底细胞癌的风险呈剂量依赖性增加（P <0.05）。在我们的队列中检测到的肿瘤表现出与阳光照射相关的非黑色素瘤皮肤癌相似的生物学行为。仔细监测和早期发现应限制与这些肿瘤相关的发病率。
Continued prospective study of the 1,380 patients enrolled in the PUVA study for 10 years after first exposure to PUVA demonstrates a strong association between cumulative exposure to PUVA and an increased risk of squamous cell carcinoma of the skin. For tumors occurring at least 58 months after first treatment, after adjustment for age, sex, and area of residence, we observed that patients with more than 260 treatments had an 11-fold increase in risk compared to patients who had received 160 or fewer treatments during the same interval (P less than 0.01). Comparable increases in relative risk were noted in patients of all skin types, irrespective of prior ionizing radiation exposure. We also noted a modest dose-dependent increase in the risk for the development of basal cell carcinoma for patients who received an excess of 200 treatments compared to those who had received fewer than 160 treatments within the same time period (P less than 0.05). Tumors detected in our cohort exhibit biologic behavior similar to non-melanoma skin cancers associated with sun exposure. Careful monitoring and early detection should limit the morbidity associated with these tumors.
8-甲氧基补骨脂素和长波紫外线辐射 (PUVA) 的全身作用可延长小鼠皮肤同种异体移植物的存活率。
DOI：
10.1111/1523-1747.ep12469766
发表时间：
1987
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Granstein,RD;Smith,L;Parrish,JA
通讯作者：
Parrish,JA