Brain stem catecholamine mechanisms in tonic and reflex control of blood pressure.
Brain stem catecholamine mechanisms in tonic and reflex control of blood pressure.
复制标题
脑干儿茶酚胺在血压的强直和反射控制中的机制。
作者：
Donald J. Reis;Antonio Granata;Tong H. Joh;C. Ross;D. Ruggiero;Dong H. Park
下脑干的神经元维持动脉压（AP）的静息水平，介导来自心肺受体的反射反应，并且是α 2-肾上腺素能激动剂的兴奋作用的重要部位。有关AP的紧张性和反射性调节的通路和递质的详细信息正在出现。第九和第十神经中心肺感受器的传入纤维终止于双侧孤束核（NTS）。虽然有些神经元含有P物质，但主要的神经递质似乎是兴奋性氨基酸L-谷氨酸（L-glu）。延髓头端腹外侧区的神经元，很可能包括C1肾上腺素神经元，在AP控制中也很关键。C1神经元投射以支配脊髓中的胆碱能节前交感神经元。电刺激C1区或用L-glu刺激可增加AP，而损伤或局部注射抑制性氨基酸γ-氨基丁酸（GABA）可将AP降低至与脊髓横断相当的水平。C1神经元或其通路的损伤可消除压力感受器和迷走神经传入的血管降压反射。相反，去甲肾上腺素能神经元的尾侧腹外侧髓质，A1组，项目rostrally支配，部分，下丘脑的加压素神经元。A1神经元的刺激降低AP，而病变或GABA升高it. We建议，C1神经元包括所谓的紧张性血管紧张中心的脑干，也调解，通过从NTS的投射，压力感受性反射的vasodepressor肢体。NTS-C1投射可能是GABA能的。
Neurons of the lower brain stem maintain resting levels of arterial pressure (AP), mediate reflex responses from cardiopulmonary receptors, and are an important site of the hypotensive actions of alpha 2-adrenergic agonists. Details of the pathways and transmitters that mediate tonic and reflex control of AP are emerging. Afferent fibers of cardiopulmonary receptors in the ninth and tenth nerves terminate bilaterally in the nucleus of the tractus solitarius (NTS). Although some neurons contain substance P, the primary neurotransmitter appears to be the excitatory amino acid L-glutamate (L-glu). Neurons in rostral ventrolateral medulla, which most probably comprise the C1 group of epinephrine neurons, are also critical in AP control. C1 neurons project to innervate cholinergic preganglionic sympathetic neurons in the spinal cord. Stimulation of the C1 area electrically or with L-glu increases AP, while lesions or local injection of the inhibitory amino acid gamma-aminobutyric acid (GABA) lowers AP to levels comparable to spinal cord transection. Lesions of C1 neurons or their pathways abolish vasodepressor reflexes from baroreceptors and vagal afferents. In contrast, noradrenergic neurons of the caudal ventrolateral medulla, the A1 group, project rostrally to innervate, in part, vasopressin neurons of the hypothalamus. Stimulation of A1 neurons lowers AP, while lesions or GABA elevates it. We propose that C1 neurons comprise the so-called tonic vasomotor center of the brain stem and also mediate, via a projection from the NTS, the vasodepressor limb of baroreflexes. The NTS-C1 projection may be GABAergic.
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孤束核中的谷氨酸机制在血压控制中。
DOI：
--
发表时间：
1984
期刊：
Federation proceedings
影响因子：
--
作者：
Talman,WT;Granata,AR;Reis,DJ
通讯作者：
Reis,DJ
影响因子：
5
作者：
L. Criscione;D. Reis;W. Talman
通讯作者：
L. Criscione;D. Reis;W. Talman
谷氨酸二乙酯阻断孤束核神经元的兴奋和由迷走神经刺激引起的反射性血管抑制反应。
影响因子：
5
作者：
Granata,AR;Reis,DJ
通讯作者：
Reis,DJ
脑干功能障碍引起的实验性中枢神经源性高血压：高血压中枢神经失衡假说的证据。
DOI：
--
发表时间：
1981
期刊：
Research publications - Association for Research in Nervous and Mental Disease
影响因子：
--
作者：
Reis,DJ
通讯作者：
Reis,DJ