The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer.
The potential role of m6A reader YTHDF1 as diagnostic biomarker and the signaling pathways in tumorigenesis and metastasis in pan-cancer.
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DOI：
10.1038/s41420-023-01321-4
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发表时间：
2023-01-28
影响因子：
7
通讯作者：
Yang, Zuozhang
中科院分区：
文献类型：
--
作者：
Zhu, Yanan;Li, Jing;Yang, Hang;Yang, Xinyi;Zhang, Ya;Yu, Xinchao;Li, Ying;Chen, Gangxian;Yang, Zuozhang
m6A在各种人类癌症的进展中是一个重要的RNA甲基化。据报道，作为m6A解读蛋白，YTHDF1可加速细胞质中m6A修饰mrna的翻译。它在各种人类癌症中高度表达，并有助于癌症的进展和转移。YTHDF1与不良预后密切相关，也被用作人类癌症临床诊断或治疗的分子标志物。据报道，它通过增加靶分子mRNA的稳定性来促进对阿霉素、顺铂和奥拉帕尼的化学耐药。此外，它有助于肿瘤细胞的csc样特性和诱导抗肿瘤免疫微环境。在此，我们就YTHDF1的临床诊断和预后价值，以及YTHDF1在人类癌症进展和转移中的分子机制进行综述。
m6A is an important RNA methylation in progression of various human cancers. As the m6A reader protein, YTHDF1 is reported to accelerate m6A-modified mRNAs translation in cytoplasm. It is highly expressed in various human cancers and contributes to the progression and metastasis of cancers. YTHDF1 was closely associated with poor prognosis and also used as a molecular marker for clinical diagnosis or therapy in human cancers. It has been reported to promote chemoresistance to Adriamycin, Cisplatin and Olaparib by increasing mRNA stability of its target molecule. Moreover, it contributes to CSC-like characteristic of tumor cells and inducing the antitumor immune microenvironment. Here, we reviewed the clinical diagnostic and prognostic values of YTHDF1, as well as the molecular mechanisms of YTHDF1 in progression and metastasis of human cancers.
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