Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five-center case-control study.
Impact of YTHDF1 gene polymorphisms on Wilms tumor susceptibility: A five-center case-control study.
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DOI：
10.1002/jcla.23875
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发表时间：
2021-08
影响因子：
2.7
通讯作者：
Bian J
中科院分区：
文献类型：
--
作者：
Liu Y;Lin H;Hua RX;Zhang J;Cheng J;Li S;Zhou H;Zhuo Z;Bian J
肾母细胞瘤是儿童最常见的肾脏恶性肿瘤。YTHDF 1与几种癌症的发生有关，但YTHDF 1基因的常见变体是否会影响Wilms肿瘤的风险尚不清楚。我们在这里提出了一项基于医院的病例对照研究，专门用于研究YTHDF 1遗传变异对Wilms肿瘤的作用。我们成功地对从中国五家医院收集的408例肾母细胞瘤病例和1198例对照进行了基因分型。采用非条件Logistic回归分析YTHDF 1基因单核苷酸多态性（SNPs）与肾母细胞瘤发病的关系。计算OR值和95%可信区间（CI），评价YTHDF 1基因SNPs（rs6011668 C>T，rs6090311 A>G）的遗传易感性。这两个SNPs都不能增加肾母细胞瘤的风险。在保护性基因型对肾母细胞瘤风险的联合作用中也检测到负相关。分层分析显示，与CC基因型相比，rs6011668 CT/TT基因型与≤18个月的肾母细胞瘤风险增加相关（OR = 1.54，95%CI = 1.02-2.30，p = 0.038），并且在>18个月的那些中具有降低的Wilms肿瘤风险（OR = 0.70，95%CI = 0.50-0.97，p = 0.034）。我们目前的工作揭示了YTHDF 1基因多态性对肾母细胞瘤风险的潜在作用。YTHDF 1基因SNPs（rs6011668 C>T，rs6090311 A>G）与肾母细胞瘤的发病风险无关。在保护性基因型对肾母细胞瘤风险的联合作用中也检测到负相关。分层分析显示，与CC基因型相比，rs6011668 CT/TT基因型在≤18个月时与肾母细胞瘤风险增加相关，在>18个月时与肾母细胞瘤风险降低相关。
Wilms tumor is the most frequent renal malignancy in children. YTHDF1 is associated with the development of several kinds of cancers, yet whether common variants of the YTHDF1 gene influence Wilms tumor risk is unknown. We present, here, a hospital‐based case‐control study specifically designed to investigate the role of YTHDF1 genetic variants on Wilms tumor. We successfully genotyped samples of 408 Wilms tumor cases and 1198 controls which were collected from five hospitals across China. The unconditional logistic regression was adopted to analyze the contributions of YTHDF1 gene single nucleotide polymorphisms (SNPs) to the risk of Wilms tumor. The odds ratio (OR) and 95% confidence interval (CI) were generated to evaluate the conferring risk of YTHDF1 gene SNPs (rs6011668 C>T, rs6090311 A>G). Neither of the two SNPs could contribute to the risk of Wilms tumor. A negative association was also detected in the combined effects of protective genotypes on Wilms tumor risk. The stratification analysis revealed that compared with those with CC genotype, rs6011668 CT/TT genotype was associated with increased Wilms tumor risk in those ≤18 months (OR = 1.54, 95% CI = 1.02–2.30, p = 0.038), and with decreased Wilms tumor risk in those >18 months (OR = 0.70, 95% CI = 0.50–0.97, p = 0.034). Our present work sheds some light on the potential role of YTHDF1 gene polymorphisms on Wilms tumor risk. YTHDF1 gene SNPs (rs6011668 C>T, rs6090311 A>G) could not contribute to the risk of Wilms tumor. A negative association was also detected in the combined effects of protective genotypes on Wilms tumor risk. The stratification analysis revealed that compared with those with CC genotype, rs6011668 CT/TT genotype was associated with increased Wilms tumor risk in those ≤18 months, and with decreased Wilms tumor risk in those >18 months.
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