The cellular mechanobiology of aging: from biology to mechanics.
The cellular mechanobiology of aging: from biology to mechanics.
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DOI：
10.1111/nyas.14529
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发表时间：
2021-05
影响因子：
5.2
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Bajpai A;Li R;Chen W
衰老是一个长期的、复杂的过程，它会导致生物体内的退行性物理和生物变化。衰老与细胞的永久性、渐进性生理衰退有关，它影响细胞力学生物学特征的方方面面，包括细胞骨架结构、机械敏感的信号通路和细胞内的力，以及细胞通过机械转导感知和适应组织环境中细胞外生物力学信号的能力。细胞中的这些机械生物学变化直接或间接地导致各种器官系统的功能障碍和疾病，包括心血管、肌肉骨骼、皮肤和免疫系统。本文对衰老在细胞机械生物学进行性衰退中的作用进行了严谨的研究，并建立了机制框架，以了解衰老对疾病进展的机械生物学影响，并开发新的策略来阻止和逆转衰老过程。本文还重点介绍了生物工程技术在衰老机制研究中的最新进展。
Aging is a chronic, complicated process that leads to degenerative physical and biological changes in living organisms. Aging is associated with permanent, gradual physiological cellular decay that affects all aspects of cellular mechanobiological features, including cellular cytoskeleton structures, mechanosensitive signaling pathways, and forces in the cell, as well as the cell’s ability to sense and adapt to extracellular biomechanical signals in the tissue environment through mechanotransduction. These mechanobiological changes in cells are directly or indirectly responsible for dysfunctions and diseases in various organ systems, including the cardiovascular, musculoskeletal, skin, and immune systems. This review critically examines the role of aging in the progressive decline of the mechanobiology occurring in cells, and establish mechanistic frameworks to understand the mechanobiological impacts of aging on disease progression and develop new strategies to halt and reverse the aging process. This review also highlights the recent development of novel bioengineering approaches for studying the key mechanobiological mechanisms in aging.
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