A multi-scale/multi-physics model for the theoretical study of the vascular configuration of retinal capillary plexuses based on OCTA data.
A multi-scale/multi-physics model for the theoretical study of the vascular configuration of retinal capillary plexuses based on OCTA data.
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基于OCTA数据的多尺度/多物理模型用于视网膜毛细血管丛血管形态的理论研究。
DOI：
10.1093/imammb/dqab018
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发表时间：
2022-02-22
期刊：
影响因子：
--
通讯作者：
Harris A
中科院分区：
文献类型：
--
作者：
Chiaravalli G;Guidoboni G;Sacco R;Radell J;Harris A
视网膜组织具有高度的代谢活性，负责将视觉刺激转化为电信号传递到大脑。复杂的血管结构确保了充足的血液和氧气供应，这对视网膜组织的功能和生存至关重要。迄今为止，对视网膜血管结构的配置仍然缺乏完整的了解。光学相干断层扫描血管造影术已经提供了大量关于主要视网膜毛细血管丛的成像数据，即浅毛细血管丛（SCP）、中间毛细血管丛（ICP）和深毛细血管丛（DCP）。然而，对这些数据的解释仍然存在争议。特别是，这三个毛细血管丛是串联还是并联的问题仍然是一个争论的问题。在这项工作中，我们解决这个问题，利用多尺度/多物理数学模型来量化的影响，两个假设的血管配置视网膜血流动力学和氧合。还根据毛细血管丛是串联还是并联来模拟对视网膜中央静脉阻塞（CRVO）和眼内压（IOP）升高的响应。模拟结果表明：（i）在串联配置中，神经丛表现出不同的响应，DCP和ICP经历比SCP更大的压降;以及（ii）在并联配置中，血流在三个神经丛中均匀地重新分布。不同的血管构型在氧分布方面也显示出不同的反应：（i）在串联构型中，外核层、外网状层和内核层（INL）是受CRVO和IOP升高影响最大的那些;以及（ii）在并联构型中，INL和神经节细胞层是受影响最大的那些。系列结果与继发于CRVO的中央旁急性中间黄斑病变的研究和IOP升高的研究一致，其中DCP和ICP及其周围的视网膜组织是受缺血影响最大的组织。这些发现似乎表明，串联配置更好地描述了健康和疾病的视网膜毛细血管网络的生理。
The retinal tissue is highly metabolically active and is responsible for translating the visual stimuli into electrical signals to be delivered to the brain. A complex vascular structure ensures an adequate supply of blood and oxygen, which is essential for the function and survival of the retinal tissue. To date, a complete understanding of the configuration of the retinal vascular structures is still lacking. Optical coherence tomography angiography has made available a huge amount of imaging data regarding the main retinal capillary plexuses, namely the superficial capillary plexuses (SCP), intermediate capillary plexuses (ICP) and deep capillary plexuses (DCP). However, the interpretation of these data is still controversial. In particular, the question of whether the three capillary plexuses are connected in series or in parallel remains a matter of debate. In this work, we address this question by utilizing a multi-scale/multi-physics mathematical model to quantify the impact of the two hypothesized vascular configurations on retinal hemodynamics and oxygenation. The response to central retinal vein occlusion (CRVO) and intraocular pressure (IOP) elevation is also simulated depending on whether the capillary plexuses are connected in series or in parallel. The simulation results show the following: (i) in the in series configuration, the plexuses exhibit a differential response, with DCP and ICP experiencing larger pressure drops than SCP; and (ii) in the in parallel configuration, the blood flow redistributes uniformly in the three plexuses. The different vascular configurations show different responses also in terms of oxygen profiles: (i) in the in series configuration, the outer nuclear layer, outer plexiform layer and inner nuclear layer (INL) are those most affected by CRVO and IOP elevation; and (ii) in the in parallel configuration the INL and ganglion cell layer are those most affected. The in series results are consistent with studies on paracentral acute middle maculopathy, secondary to CRVO and with studies on IOP elevation, in which DCP and ICP and the retinal tissues surrounding them are those most affected by ischemia. These findings seem to suggest that the in series configuration better describes the physiology of the vascular retinal capillary network in health and disease.
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影响因子：
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作者：
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通讯作者：
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作者：
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作者：
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DOI：
10.1097/iae.0b013e31829477f2
发表时间：
2013-10-01
影响因子：
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作者：
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通讯作者：
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