Understanding How Microorganisms Respond to Acid pH Is Central to Their Control and Successful Exploitation.
Understanding How Microorganisms Respond to Acid pH Is Central to Their Control and Successful Exploitation.
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DOI：
10.3389/fmicb.2020.556140
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发表时间：
2020
影响因子：
5.2
通讯作者：
O'Byrne C
中科院分区：
文献类型：
--
作者：
Lund PA;De Biase D;Liran O;Scheler O;Mira NP;Cetecioglu Z;Fernández EN;Bover-Cid S;Hall R;Sauer M;O'Byrne C
来自细菌、古生菌和真核生物这三个生命领域的微生物都有必要感知和响应质子的外部和内部浓度的变化。当质子浓度较高时，酸性条件占上风，细胞必须做出适当的反应，以确保大分子和代谢过程得到足够的保护，以维持生命。虽然近几十年来，我们已经了解了许多关于微生物用来应对酸的机制，包括有机酸带来的独特挑战，但如果对微生物中酸的影响和反应有更深入的了解，仍然可以获得很多东西。在这篇观点文章中，我们概述了已知的对酸应激期间微生物生存至关重要的关键分子机制，并讨论了这些知识如何与基于微生物的应用和过程相关，这些应用和过程对人类是重要的。我们讨论了已经采取的研究方法来调查这个问题，并强调了有前景的新途径。我们讨论了酸在感染过程中对病原体的影响，并强调了在某些类型的感染治疗中使用有机酸的潜力。我们探讨了酸胁迫对光合作用微生物的影响，以及对生物技术和工业过程的影响，包括生产有机酸所需的过程。我们强调了解酸胁迫在控制食物链腐败和致病微生物方面的重要性。最后，我们邀请对微生物对低pH值反应感兴趣的同事参加由欧盟资助的名为EuroMicropH的成本行动网络，并为我们公开提供的关于这一主题的全面文献数据库做出贡献。
Microbes from the three domains of life, Bacteria, Archaea, and Eukarya, share the need to sense and respond to changes in the external and internal concentrations of protons. When the proton concentration is high, acidic conditions prevail and cells must respond appropriately to ensure that macromolecules and metabolic processes are sufficiently protected to sustain life. While, we have learned much in recent decades about the mechanisms that microbes use to cope with acid, including the unique challenges presented by organic acids, there is still much to be gained from developing a deeper understanding of the effects and responses to acid in microbes. In this perspective article, we survey the key molecular mechanisms known to be important for microbial survival during acid stress and discuss how this knowledge might be relevant to microbe-based applications and processes that are consequential for humans. We discuss the research approaches that have been taken to investigate the problem and highlight promising new avenues. We discuss the influence of acid on pathogens during the course of infections and highlight the potential of using organic acids in treatments for some types of infection. We explore the influence of acid stress on photosynthetic microbes, and on biotechnological and industrial processes, including those needed to produce organic acids. We highlight the importance of understanding acid stress in controlling spoilage and pathogenic microbes in the food chain. Finally, we invite colleagues with an interest in microbial responses to low pH to participate in the EU-funded COST Action network called EuroMicropH and contribute to a comprehensive database of literature on this topic that we are making publicly available.
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影响因子：
6.7
作者：
Childers DS;Raziunaite I;Mol Avelar G;Mackie J;Budge S;Stead D;Gow NA;Lenardon MD;Ballou ER;MacCallum DM;Brown AJ
通讯作者：
Brown AJ
影响因子：
4.2
作者：
Gerloff-Elias, Antje;Barua, Deepak;Spijkerman, Elly
通讯作者：
Spijkerman, Elly
影响因子：
28.3
作者：
Ballou ER;Avelar GM;Childers DS;Mackie J;Bain JM;Wagener J;Kastora SL;Panea MD;Hardison SE;Walker LA;Erwig LP;Munro CA;Gow NA;Brown GD;MacCallum DM;Brown AJ
通讯作者：
Brown AJ
影响因子：
8.4
作者：
Domingos, Joana M. B.;Martinez, Gonzalo A.;Bertin, Lorenzo
通讯作者：
Bertin, Lorenzo
影响因子：
8.4
作者：
Basso, Thiago O.;de Kok, Stefan;Stambuk, Boris U.
通讯作者：
Stambuk, Boris U.