Staphylococcus epidermidis--the 'accidental' pathogen.

Staphylococcus epidermidis--the 'accidental' pathogen.
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DOI:
10.1038/nrmicro2182
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发表时间:
2009-08
期刊:
Nature reviews. Microbiology
影响因子:
--
通讯作者:
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中科院分区:
其他
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Although nosocomial infections byStaphylococcus epidermidishave gained much attention, this skin-colonizing bacterium has apparently evolved not to cause disease, but to maintain the commonly benign relationship with its host. Accordingly,S. epidermidisdoes not produce aggressive virulence determinants. Rather, factors that normally sustain the commensal lifestyle ofS. epidermidisseem to give rise to additional benefits during infection. Furthermore, we are beginning to comprehend the roles ofS. epidermidisin balancing the epithelial microflora and serving as a reservoir of resistance genes. In this Review, I discuss the molecular basis of the commensal and infectious lifestyles ofS. epidermidis.
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