Characterizing in situ poroelastic properties of cytoplasm by the translation of a rigid spherical inclusion
Characterizing in situ poroelastic properties of cytoplasm by the translation of a rigid spherical inclusion
复制标题
通过刚性球形夹杂物的平移表征细胞质的原位多孔弹性特性
DOI：
10.1007/s10409-020-01038-y
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发表时间：
2021-01
影响因子：
3.5
通讯作者：
Lu Tian Jian
中科院分区：
文献类型：
--
作者：
Sun Xuechao;Chen Xin;Wang Ming;Li Moxiao;Liu Yonggang;Liu Shaobao;Lu Tian Jian
Poroelasticity of cytoplasm is a rate-and size-dependent biphasic material behavior that reflects the normal activities and pathological states of cells,mainly caused by the migration of fluid molecules and the deformation of porous solid skeleton(protein scaffold).While micro/nano-indentation tests have been extensively used to characterize the poroelasticity of a cell,characterizing the in situ poroelasticity of cytoplasm remains elusive.In this study,based on the theory of the translation of a rigid spherical inclusion,we proposed a new method to characterize the in situ poroelasticity of cytoplasm.Based on data from optical/magnetic tweezers tests,we estimated three key poroelasticity parameters—shear modulus,Poisson ratio and diffusion coefficient—of cytoplasm for a variety of cells,including cardiomyocytes,endothelial cells of bovine capillary,and fibroblasts.The proposed method provides a powerful tool for in situ measurement of poroelastic properties of cytoplasm via optical/magnetic tweezers.
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影响因子：
41.2
作者：
通讯作者：
--
影响因子：
2.4
作者：
S. Cowin
通讯作者：
S. Cowin
DOI：
--
发表时间：
2014-10
期刊：
--
影响因子：
--
作者：
Ming Guo
通讯作者：
Ming Guo
影响因子：
3.5
作者：
Zhu X;Cirovic S;Shaheen A;Xu W
通讯作者：
Xu W
影响因子：
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作者：
Han, Yu Long;Pegoraro, Adrian F.;Guo, Ming
通讯作者：
Guo, Ming