Comparison of the clinical effectiveness of zanamivir and laninamivir octanoate for children with influenza A(H3N2) and B in the 2011-2012 season.
Comparison of the clinical effectiveness of zanamivir and laninamivir octanoate for children with influenza A(H3N2) and B in the 2011-2012 season.
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DOI：
10.1111/irv.12147
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发表时间：
2014-03
影响因子：
4.4
通讯作者：
Ishiguro N
中科院分区：
文献类型：
--
作者：
Koseki N;Kaiho M;Kikuta H;Oba K;Togashi T;Ariga T;Ishiguro N
评估两种吸入性神经氨酸酶抑制剂 (NAIs) 扎那米韦 (ZN) 和辛酸拉尼米韦 (LO) 对于甲型 (H3N2) 和乙型流感病毒感染的临床疗效。 2012年1月至4月进行了一项前瞻性、多中心观察性研究。纳入年龄5-18岁、体温在37.5℃或以上、经免疫层析检测诊断为流感的门诊患者。总共对 338 名接受 ZN 治疗的患者和 314 名接受 LO 治疗的患者进行了比较。将每种 NAI 第一剂给药后的发烧持续时间作为主要终点进行评估。次要终点是双相发热的发作。 ZN 组和 LO 组之间的发烧持续时间没有发现统计学上的显着差异（对数秩检验，P = 0.117）。 Logistic回归模型显示，年龄每减少1岁，双相发热发作次数增加1.19倍（P = 0.016），且接受LO治疗的患者双相发热发作次数是接受ZN治疗的患者的5.80倍（P < 0.001）。尽管LO组的发烧持续时间与ZN组相当，但年龄较小的儿童和LO组的双相发热发作比ZN组更频繁。
To evaluate the clinical effectiveness of the two inhaled neuraminidase inhibitors (NAIs), zanamivir (ZN) and laninamivir octate (LO), for influenza A(H3N2) and B virus infections. A prospective, multicenter observational study was conducted from January to April in 2012. Outpatients aged 5–18 years who had a temperature of 37.5°C or higher and were diagnosed as having influenza based on an immunochromatographic assay were enrolled. A total of 338 patients treated with ZN and 314 patients treated with LO were compared. The duration of fever after administration of the first dose of each NAI was evaluated as a primary endpoint. The secondary endpoint was episodes of biphasic fever. No statistically significant difference in the duration of fever was found between the ZN and LO groups (log-rank test, P = 0.117). A logistic regression model showed that episodes of biphasic fever increased by 1.19 times for every decrease of 1 year of age (P = 0.016) and that the number of biphasic fever episodes in patients treated with LO was 5.80-times greater than that in patients treated with ZN (P < 0.001). Although the duration of fever in the LO group was comparable to that in the ZN group, episodes of biphasic fever were more frequent in younger children and in the LO group than in the ZN group.
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影响因子：
2.2
作者：
Sato, Maki;Saito, Reiko;Suzuki, Hiroshi
通讯作者：
Suzuki, Hiroshi
影响因子：
11.8
作者：
Watanabe, Akira;Chang, Shan-Chwen;Ohashi, Yasuo
通讯作者：
Ohashi, Yasuo
影响因子：
11.8
作者：
Kawai, Naoki;Ikematsu, Hideyuki;Kashiwagi, Seizaburo
通讯作者：
Kashiwagi, Seizaburo
影响因子：
3.1
作者：
Nakauchi M;Yasui Y;Miyoshi T;Minagawa H;Tanaka T;Tashiro M;Kageyama T
通讯作者：
Kageyama T
影响因子：
158.5
作者：
Hayden, FG;Osterhaus, ADME;Wightman, K
通讯作者：
Wightman, K