The role of PML in hematopoietic and leukemic stem cell maintenance.
The role of PML in hematopoietic and leukemic stem cell maintenance.
复制标题
PML在造血和白血病干细胞维持中的作用。
DOI：
10.1007/s12185-014-1518-x
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发表时间：
2014-07
影响因子：
2.1
通讯作者：
Ito, Keisuke
中科院分区：
文献类型：
--
作者：
Nakahara, Fumio;Weiss, Cary N.;Ito, Keisuke
肿瘤抑制因子早幼粒细胞白血病首次被鉴定为早幼粒细胞白血病α融合蛋白的一种成分，早幼粒细胞白血病是急性早幼粒细胞白血病的始发细胞遗传学异常之一。目前已知PML具有多种功能，调节DNA损伤反应、细胞凋亡、衰老和血管生成。最近的研究发现，PML是包括造血系统在内的干细胞体内代谢途径的调节因子，并为研究人员提供了控制干细胞维持和分化的新策略。对白血病起始细胞中PML的研究表明，PML也是其维持的重要组成部分，这引起了各个干细胞领域的科学家对PML的极大关注。在这里，我们回顾了PML及其相关途径的研究，包括PML与干细胞生物学相关的最新研究，以及我们的发现，PML调节脂肪酸氧化，这是维持正常造血干细胞所必需的。我们还讨论了控制PML相关通路的治疗潜力。特别是，我们描述了三氧化二砷用于慢性粒细胞白血病治疗的有希望的证据。
The tumor suppressor promyelocytic leukemia (PML) was first identified as a component of PML–RARα fusion protein, one of the initiating cytogenetic abnormalities in acute promyelocytic leukemia. PML is now known to have diverse functions regulating the DNA-damage response, apoptosis, senescence, and angiogenesis. Recent investigations have identified PML as a regulator of metabolic pathways in stem cell compartments, including the hematopoietic system, and have provided researchers with new strategies for controlling stem cell maintenance and differentiation. Studies of PML in leukemia-initiating cells demonstrate that PML is also an essential component of their maintenance, which has drawn tremendous attention to PML from scientists in various stem cell fields. Here, we review research into PML and its associated pathways, including recent studies of PML as it relates to stem cell biology, as well as our finding that PML regulates fatty acid oxidation, which is essential to the maintenance of normal hematopoietic stem cells. We also discuss the therapeutic potential of controlling PML-associated pathways. In particular, we describe promising evidence for the use of arsenic trioxide in the treatment of chronic myeloid leukemia.
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影响因子：
64.5
作者：
Brunet, A;Bonni, A;Greenberg, ME
通讯作者：
Greenberg, ME
影响因子：
11.2
作者：
Dang CV
通讯作者：
Dang CV
影响因子：
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作者：
Carracedo, Arkaitz;Weiss, Dror;Pandolfi, Pier P.
通讯作者：
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影响因子：
8
作者：
Buzzai, M;Bauer, DE;Thompson, CB
通讯作者：
Thompson, CB
DOI：
10.1073/pnas.0807640106
发表时间：
2009-03-24
影响因子：
11.1
作者：
Li, Wenjing;Ferguson, Brian J.;Watson, Christine J.
通讯作者：
Watson, Christine J.