Interventions to Improve Adherence to Antiretroviral Therapy (ART) in Sub-Saharan Africa: An Updated Systematic Review.
Interventions to Improve Adherence to Antiretroviral Therapy (ART) in Sub-Saharan Africa: An Updated Systematic Review.
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DOI：
10.3390/ijerph18052477
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发表时间：
2021-03-03
影响因子：
--
通讯作者：
Agbaji O
中科院分区：
文献类型：
--
作者：
Damulak PP;Ismail S;Abdul Manaf R;Mohd Said S;Agbaji O
对抗逆转录病毒疗法(ART)的最佳坚持仍然是有效治疗和管理人类免疫缺陷病毒(HIV)的基石。这项系统的审查审查了干预措施在撒哈拉以南非洲(SSA)改善抗逆转录病毒治疗的效果，该地区承担着全球最大的艾滋病毒感染负担。根据Prisma指南，根据我们的纳入和排除标准，在PubMed、MEDLINE和Google Scholar数据库中搜索2010至2019年间已发表的关于抗逆转录病毒治疗依从性干预的研究。确定了2010至2019年间发表的31项符合条件的研究，干预措施的类别为结构、行为、生物、认知和组合。研究特征在设计、干预类型、干预环境、国家和结果测量方面各不相同。许多研究是在医院进行的行为干预，更多的研究是随机对照试验(RCT)干预。尽管研究存在差异，但仍有24项研究记录了改善。尽管如此，应该进行更多的高质量研究，如随机对照试验，特别是在主要受影响人群(KAP)中，以控制该病毒耐药株的传播。可靠的遵守客观衡量标准应该取代传统的主观自我报告。此外，在评估干预措施的有效性时，应考虑持续时间较长的长期干预措施。
Optimal adherence to antiretroviral therapy (ART) remains the bedrock of effective therapy and management of human immunodeficiency virus (HIV). This systematic review examines the effect of interventions in improving ART adherence in sub-Saharan Africa (SSA), which bears the largest global burden of HIV infection. In accordance with PRISMA guidelines, and based on our inclusion and exclusion criteria, PUBMED, MEDLINE, and Google Scholar databases were searched for published studies on ART adherence interventions from 2010 to 2019. Thirty-one eligible studies published between 2010 to 2019 were identified, the categories of interventions were structural, behavioral, biological, cognitive, and combination. Study characteristics varied across design, intervention type, intervention setting, country, and outcome measurements. Many of the studies were behavioral interventions conducted in hospitals with more studies being randomized controlled trial (RCT) interventions. Despite the study variations, twenty-four studies recorded improvements. Notwithstanding, more quality studies such as RCTs should be conducted, especially among key affected populations (KAPs) to control transmission of resistant strains of the virus. Reliable objective measures of adherence should replace the conventional subjective self-report. Furthermore, long-term interventions with longer duration should be considered when evaluating the effectiveness of interventions.
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DOI：
10.1097/00042560-200205010-00014
发表时间：
2002-05-01
期刊：
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
影响因子：
--
作者：
de Olalla, PG;Knobel, H;Caylà, JA
通讯作者：
Caylà, JA
影响因子：
15.8
作者：
Chung, Michael H.;Richardson, Barbra A.;John-Stewart, Grace C.
通讯作者：
John-Stewart, Grace C.
DOI：
10.1056/nejmoa1600693
发表时间：
2016-09-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cohen MS;Chen YQ;McCauley M;Gamble T;Hosseinipour MC;Kumarasamy N;Hakim JG;Kumwenda J;Grinsztejn B;Pilotto JH;Godbole SV;Chariyalertsak S;Santos BR;Mayer KH;Hoffman IF;Eshleman SH;Piwowar-Manning E;Cottle L;Zhang XC;Makhema J;Mills LA;Panchia R;Faesen S;Eron J;Gallant J;Havlir D;Swindells S;Elharrar V;Burns D;Taha TE;Nielsen-Saines K;Celentano DD;Essex M;Hudelson SE;Redd AD;Fleming TR;HPTN 052 Study Team
通讯作者：
HPTN 052 Study Team
影响因子：
56.3
作者：
Baernighausen, Till;Chaiyachati, Krisda;Chimbindi, Natsayi;Peoples, Ashleigh;Haberer, Jessica;Newell, Marie-Louise
通讯作者：
Newell, Marie-Louise
影响因子：
3.8
作者：
Bangsberg, DR;Perry, S;Moss, A
通讯作者：
Moss, A