Phagocytic astrocytes: Emerging from the shadows of microglia.
Phagocytic astrocytes: Emerging from the shadows of microglia.
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作者：
在健康和患病的中枢神经系统(CNS)中，死亡或活细胞的清除都是发生的。死亡或死亡的细胞被吞噬作用迅速清除，以维持健康的中枢神经系统或在受伤后恢复。活细胞或其部分，如突触和髓鞘，通过吞噬作用被适当地消除，以维持或完善发育和成年期的神经网络。小胶质细胞是中枢神经系统中驻留的巨噬细胞的一种特殊类型，经典地被认为是初级吞噬细胞；然而，在过去的十年里，星形胶质细胞也被强调为吞噬细胞。据报道，吞噬靶点和受体主要存在于星形胶质细胞和小胶质细胞之间，这就提出了一个问题，即星形胶质细胞吞噬作用与小胶质细胞吞噬作用有何不同，这两个吞噬细胞系统是如何相互作用的。在这篇综述中，我们将讨论星形胶质细胞吞噬的后果，特别关注这些难以捉摸的点。吞噬靶细胞多见于星形胶质细胞和小胶质细胞。不同的因素决定了这两种神经胶质细胞是否能吞噬靶细胞。星形胶质细胞和小胶质细胞的相互作用可能为小胶质细胞提供吞噬优势。
Elimination of dead or live cells take place in both a healthy and diseased central nervous system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance of a healthy CNS or for recovery after injury. Live cells or parts thereof, such as the synapses and myelin, are appropriately eliminated by phagocytosis to maintain or refine neural networks during development and adulthood. Microglia, the specific population of resident macrophages in the CNS, are classically considered as primary phagocytes; however, astrocytes have also been highlighted as phagocytes in the last decade. Phagocytic targets and receptors are reported to be mostly common between astrocytes and microglia, which raises the question of how astrocytic phagocytosis differs from microglial phagocytosis, and how these two phagocytic systems cooperate. In this review, we address the consequences of astrocytic phagocytosis, particularly focusing on these elusive points. Phagocytic targets are mostly common between astrocytes and microglia. Various factors determine whether either of the glial cell types phagocytose the targets. Interaction of astrocytes and microglia may provide microglia with a phagocytic advantage.
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影响因子：
9.2
作者：
Bernardinelli, Yann;Randall, Jerome;Muller, Dominique
通讯作者：
Muller, Dominique
影响因子：
16.2
作者：
Armand EJ;Li J;Xie F;Luo C;Mukamel EA
通讯作者：
Mukamel EA
影响因子：
12.7
作者：
Cignarella, Francesca;Filipello, Fabia;Piccio, Laura
通讯作者：
Piccio, Laura
影响因子：
9.8
作者：
Abiega O;Beccari S;Diaz-Aparicio I;Nadjar A;Layé S;Leyrolle Q;Gómez-Nicola D;Domercq M;Pérez-Samartín A;Sánchez-Zafra V;Paris I;Valero J;Savage JC;Hui CW;Tremblay MÈ;Deudero JJ;Brewster AL;Anderson AE;Zaldumbide L;Galbarriatu L;Marinas A;Vivanco Md;Matute C;Maletic-Savatic M;Encinas JM;Sierra A
通讯作者：
Sierra A
影响因子：
17.1
作者：
Alawieh A;Langley EF;Tomlinson S
通讯作者：
Tomlinson S