Mitochondrial uncoupling and lifespan.
Mitochondrial uncoupling and lifespan.
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DOI：
10.1016/j.mad.2010.03.010
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发表时间：
2010-07
影响因子：
5.3
通讯作者：
Brand, Martin D.
中科院分区：
文献类型：
--
作者：
Mookerjee, Shona A.;Divakaruni, Ajit S.;Jastroch, Martin;Brand, Martin D.
为了了解我们衰老的原因，已经开展了许多研究，这些研究逐渐融合到线粒体活动对代谢的控制中。也就是说，营养摄取、转化为可用能量和减少有害副产物之间的理想平衡可以通过线粒体呼吸和输出（ATP、活性氧（ROS）和热量）来调节。质子泄漏导致线粒体效率低下，导致底物氧化与ADP磷酸化分离，可占基础代谢率的30%。假设这种解偶联可以保护细胞免受有利于ROS产生的条件的影响。解偶联也可以通过药物诱导质子泄漏和解偶联蛋白的活性来发生。线粒体解偶联通过对代谢率和活性氧产生的影响而与寿命延长有关。然而，迄今为止的证据并不表明解耦在寿命中起一致的作用。这篇综述的目的是讨论最近研究线粒体解偶联如何影响寿命的工作。
The quest to understand why we age has given rise to numerous lines of investigation that have gradually converged to include metabolic control by mitochondrial activity as a major player. That is, the ideal balance between nutrient uptake, its transduction into usable energy, and the mitigation of damaging byproducts can be regulated by mitochondrial respiration and output (ATP, reactive oxygen species (ROS), and heat). Mitochondrial inefficiency through proton leak, which uncouples substrate oxidation from ADP phosphorylation, can comprise as much as 30% of the basal metabolic rate. This uncoupling is hypothesized to protect cells from conditions that favor ROS production. Uncoupling can also occur through pharmacological induction of proton leak and activity of the uncoupling proteins. Mitochondrial uncoupling is implicated in lifespan extension through its effects on metabolic rate and ROS production. However, evidence to date does not suggest a consistent role for uncoupling in lifespan. The purpose of this review is to discuss recent work examining how mitochondrial uncoupling impacts lifespan.
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影响因子：
9.8
作者：
Bordone L;Motta MC;Picard F;Robinson A;Jhala US;Apfeld J;McDonagh T;Lemieux M;McBurney M;Szilvasi A;Easlon EJ;Lin SJ;Guarente L
通讯作者：
Guarente L
影响因子：
3.9
作者：
Chan, C. B.;Kashemsant, N.
通讯作者：
Kashemsant, N.
DOI：
10.1111/j.1749-6632.1998.tb09905.x
发表时间：
1998-01-01
期刊：
TOWARDS PROLONGATION OF THE HEALTHY LIFE SPAN
影响因子：
--
作者：
Barja, G
通讯作者：
Barja, G
影响因子：
4.3
作者：
Adams, Alison E.;Hanrahan, Orla;Porter, Richard K.
通讯作者：
Porter, Richard K.
影响因子：
3.5
作者：
Boss, O;Samec, S;Giacobino, JP
通讯作者：
Giacobino, JP