Cytoskeleton-Associated Protein 4, a Promising Biomarker for Tumor Diagnosis and Therapy.
Cytoskeleton-Associated Protein 4, a Promising Biomarker for Tumor Diagnosis and Therapy.
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细胞骨架相关蛋白 4，一种有前途的肿瘤诊断和治疗生物标志物。
DOI：
10.3389/fmolb.2020.552056
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发表时间：
2020
影响因子：
5
通讯作者：
Guo ZY
中科院分区：
文献类型：
--
作者：
Li SX;Li J;Dong LW;Guo ZY
细胞凋亡相关蛋白4（CKAP 4）位于粗面内质网（ER）中，对稳定ER结构起重要作用。同时，CKAP 4也被发现作为细胞表面的活化受体。随着越来越多的研究证据，CKAP 4的多功能性逐渐被发现。除了参与包括细胞增殖、细胞迁移和稳定ER结构的各种生理事件外，CKAP 4还与肿瘤发生有关。然而，CKAP 4在肿瘤生物学中的作用仍存在争议，这可能与在不同的微环境中结合不同的配体介导不同的信号转导途径有关。有趣的是，CKAP 4最近被认为是几种肿瘤的血清学标志物，并且CKAP 4有望成为肿瘤治疗靶点。因此，破译CKAP 4在不同疾病中的基因状态、表达调控、功能可能会为基于CKAP 4的癌症诊断和治疗策略提供新的线索。这篇综述讨论了描述CKAP 4在各种疾病中的出版物，特别是在肿瘤促进和抑制方面，并对差异进行了详细的讨论。
Cytoskeleton-associated protein 4 (CKAP4) is located in the rough endoplasmic reticulum (ER) and plays an important role in stabilizing the structure of ER. Meanwhile, CKAP4 is also found to act as an activated receptor at the cell surface. The multifunction of CKAP4 was gradually discovered with growing research evidence. In addition to the involvement in various physiological events including cell proliferation, cell migration, and stabilizing the structure of ER, CKAP4 has been implicated in tumorigenesis. However, the role of CKAP4 is still controversial in tumor biology, which may be related to different signal transduction pathways mediated by binding to different ligands in various microenvironments. Interestingly, CKAP4 has been recently recognized as a serological marker of several tumors and CKAP4 is expected to be a tumor therapeutic target. Therefore, deciphering the gene status, expression regulation, functions of CKAP4 in different diseases may shed new light on CKAP4-based cancer diagnosis and therapeutic strategy. This review discusses the publications that describe CKAP4 in various diseases, especially on tumor promotion and suppression, and provides a detailed discussion on the discrepancy.
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