What are the origins and relevance of spontaneous bladder contractions? ICI-RS 2017.
What are the origins and relevance of spontaneous bladder contractions? ICI-RS 2017.
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DOI：
10.1002/nau.23485
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发表时间：
2018-06
影响因子：
2
通讯作者：
McCloskey KD
中科院分区：
文献类型：
--
作者：
Drake MJ;Fry CH;Hashitani H;Kirschner-Hermanns R;Rahnama'i MS;Speich JE;Tomoe H;Kanai AJ;McCloskey KD
储存期膀胱活动是自发收缩的反直觉观察。它们可能是平滑肌的固有特征，但粘膜和逼尿肌本身中的间质细胞以及粘膜中的其他肌肉成分可能会对它们产生实质性影响。它们在解释下尿路功能障碍的几种模型中被确定。2017年国际膀胱研究学会（ICI-RS）大会上的一次共识会议通过辩论哪些细胞类型调节膀胱自发活动，方法是否足够稳健以及对健康和异常下尿路功能的影响，考虑了自发性膀胱收缩的起源和相关性。确定的研究重点反映了广泛的未知方面。逼尿肌平滑肌自发收缩的细胞贡献仍然不确定。因此，深入了解膀胱壁的细胞生理学，特别是平滑肌细胞、间质细胞和尿路上皮细胞，仍然很重要。上游的影响，如神经支配，内分泌和旁分泌因素，是特别重要的。细胞间的相互作用代表了对器官功能的综合生理学的关键理解，特别是粘膜和逼尿肌层之间的信号传导的性质。事实上，尚不清楚在分离的制剂中产生的自发收缩在多大程度上反映了它们在完整膀胱中的正常和病理对应物。还需要改进自发收缩如何影响压力产生和感觉神经功能的模型。自发性收缩及其对实验和临床使用的影响的可靠评估的衍生方法可能会在功能性泌尿学方面取得相当大的进展。
Storage phase bladder activity is a counter-intuitive observation of spontaneous contractions. They are potentially an intrinsic feature of the smooth muscle, but interstitial cells in the mucosa and the detrusor itself, as well as other muscular elements in the mucosa may substantially influence them. They are identified in several models explaining lower urinary tract dysfunction. A consensus meeting at the International Consultation on Incontinence Research Society (ICI-RS) 2017 congress considered the origins and relevance of spontaneous bladder contractions by debating which cell type(s) modulate bladder spontaneous activity, whether the methodologies are sufficiently robust, and implications for healthy and abnormal lower urinary tract function. The identified research priorities reflect a wide range of unknown aspects. Cellular contributions to spontaneous contractions in detrusor smooth muscle are still uncertain. Accordingly, insight into the cellular physiology of the bladder wall, particularly smooth muscle cells, interstitial cells, and urothelium, remains important. Upstream influences, such as innervation, endocrine, and paracrine factors, are particularly important. The cellular interactions represent the key understanding to derive the integrative physiology of organ function, notably the nature of signaling between mucosa and detrusor layers. Indeed, it is still not clear to what extent spontaneous contractions generated in isolated preparations mirror their normal and pathological counterparts in the intact bladder. Improved models of how spontaneous contractions influence pressure generation and sensory nerve function are also needed. Deriving approaches to robust evaluation of spontaneous contractions and their influences for experimental and clinical use could yield considerable progress in functional urology.
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影响因子：
4.5
作者：
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DOI：
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