Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA.
Clinical biomarkers of pulmonary carcinoid tumors in never smokers via profiling miRNA and target mRNA.
复制标题
通过分析 miRNA 和靶标 mRNA 分析从不吸烟者的肺类癌临床生物标志物
DOI：
10.1186/2045-3701-4-35
复制
发表时间：
2014
影响因子：
7.5
通讯作者：
Yang P
中科院分区：
文献类型：
--
作者：
Deng B;Molina J;Aubry MC;Sun Z;Wang L;Eckloff BW;Vasmatzis G;You M;Wieben ED;Jen J;Wigle DA;Yang P
BackgroundmiRNAs play key regulatory roles in cellular pathological processes. We aimed to identify clinically meaningful biomarkers in pulmonary carcinoid tumors (PCTs), a member of neuroendocrine neoplasms, via profiling miRNAs and mRNAs.ResultsFrom the total of 1145 miRNAs, we obtained 16 and 17 miRNAs that showed positive and negative fold changes (FCs, tumors vs. normal tissues) in the top 1% differentially expressed miRNAs, respectively. We uncovered the target genes that were predicted by at least two prediction tools and overlapped by at least one-half of the top miRNAs, which yielded 44 genes (FC<-2) and 56 genes (FC>2), respectively. Higher expressions ofCREB5,PTPRBandCOL4A3predicted favorable disease free survival (Hazard ratio: 0.03, 0.19 and 0.36; P value: 0.03, 0.03 and 0.08). Additionally, 79 mutated genes have been found in nine PCTs where TP53 was the only repeated mutation.ConclusionWe identified that the expressions of three genes have clinical implications in PCTs. The biological functions of these biomarkers warrant further studies.
登录
查看更多内容
影响因子：
14.9
作者：
Betel D;Wilson M;Gabow A;Marks DS;Sander C
通讯作者：
Sander C
DOI：
10.1016/j.bbrc.2011.05.036
发表时间：
2011-06-10
影响因子：
3.1
作者：
Adrian Lopez, Jesus;Marat Alvarez-Salas, Luis
通讯作者：
Marat Alvarez-Salas, Luis
影响因子：
11.2
作者：
Corney, David C.;Flesken-Nikitin, Andrea;Nikitin, Alexander Yu.
通讯作者：
Nikitin, Alexander Yu.
影响因子：
4.4
作者：
Clarke C;Henry M;Doolan P;Kelly S;Aherne S;Sanchez N;Kelly P;Kinsella P;Breen L;Madden SF;Zhang L;Leonard M;Clynes M;Meleady P;Barron N
通讯作者：
Barron N
影响因子：
3.4
作者：
Naalsund, Anne;Rostad, Hans;Strand, Trond-Eirik
通讯作者：
Strand, Trond-Eirik