Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness.
Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness.
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DOI：
10.1172/jci.insight.163150
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发表时间：
2023-02-08
期刊：
影响因子：
8
通讯作者：
Utz, Paul J.
中科院分区：
文献类型：
--
作者：
Feng, Allan;Yang, Emily Y.;Moore, Andrew Reese;Dhingra, Shaurya;Chang, Sarah Esther;Yin, Xihui;Pi, Ruoxi;Mack, Elisabeth K. M.;Voelkel, Sara;Gessner, Reinhard;Guendisch, Margrit;Neubauer, Andreas;Renz, Harald;Tsiodras, Sotirios;Fragkou, Paraskevi C.;Asuni, Adijat A.;Levitt, Joseph E.;Wilson, Jennifer G.;Leong, Michelle;Lumb, Jennifer H.;Mao, Rong;Pinedo, Kassandra;Roque, Jonasel;Richards, Christopher M.;Stabile, Mikayla;Swaminathan, Gayathri;Salagianni, Maria L.;Triantafyllia, Vasiliki;Bertrams, Wilhelm;Blish, Catherine A.;Carette, Jan E.;Frankovich, Jennifer;Meffre, Eric;Nadeau, Kari Christine;Singh, Upinder;Wang, Taia T.;Prak, Eline T. Luning;Herold, Susanne;Andreakos, Evangelos;Schmeck, Bernd;Skevaki, Chrysanthi;Rogers, Angela J.;Utz, Paul J.
SARS-CoV-2急性感染中自身抗体的广泛存在越来越被人们所认识，但自身抗体在非SARS-CoV-2感染和危重病中的流行尚未报道。我们分析了来自5个独立队列的267例非SARS-CoV-2病毒性、细菌性和非感染性危重病患者的IgG自身抗体。使用Luminex阵列筛选血清样品，其中包括58种细胞因子和55种自身抗原，其中许多与结缔组织疾病（CTD）相关。使用基于细胞的功能测定法测试抗细胞因子抗体阳性的样品的受体阻断活性。在所有5个急性病群组中，在> 50%的患者中鉴定出抗细胞因子抗体。在重症患者中，抗细胞因子抗体在感染患者中比未感染患者更常见。在基于细胞的功能测定中，39份选定抗细胞因子抗体阳性样品中有11份显示出对I型IFN、GM-CSF和IL-6表面受体的受体阻断活性。还经常观察到针对CTD相关自身抗原的自身抗体，包括纵向样本中出现的新检测到的抗体。这些发现表明，抗细胞因子和自身抗体在不同的病毒和非病毒感染中是常见的，并且在疾病的严重程度上是不同的。
The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly recognized, but the prevalence of autoantibodies in non–SARS-CoV-2 infections and critical illness has not yet been reported. We profiled IgG autoantibodies in 267 patients from 5 independent cohorts with non–SARS-CoV-2 viral, bacterial, and noninfectious critical illness. Serum samples were screened using Luminex arrays that included 58 cytokines and 55 autoantigens, many of which are associated with connective tissue diseases (CTDs). Samples positive for anti-cytokine antibodies were tested for receptor blocking activity using cell-based functional assays. Anti-cytokine antibodies were identified in > 50% of patients across all 5 acutely ill cohorts. In critically ill patients, anti-cytokine antibodies were far more common in infected versus uninfected patients. In cell-based functional assays, 11 of 39 samples positive for select anti-cytokine antibodies displayed receptor blocking activity against surface receptors for Type I IFN, GM-CSF, and IL-6. Autoantibodies against CTD-associated autoantigens were also commonly observed, including newly detected antibodies that emerged in longitudinal samples. These findings demonstrate that anti-cytokine and autoantibodies are common across different viral and nonviral infections and range in severity of illness.
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影响因子：
5.8
作者：
Gu, Zuguang;Eils, Roland;Schlesner, Matthias
通讯作者：
Schlesner, Matthias
DOI：
10.1186/s12969-017-0205-x
发表时间：
2017-10-31
期刊：
Pediatric rheumatology online journal
影响因子：
--
作者：
Binns EL;Moraitis E;Maillard S;Tansley S;McHugh N;Jacques TS;Wedderburn LR;Pilkington C;Yasin SA;Nistala K;UK Juvenile Dermatomyositis Research Group (UK and Ireland)
通讯作者：
UK Juvenile Dermatomyositis Research Group (UK and Ireland)
危及生命的Covid-19患者中针对I型IFN的自身抗体。
DOI：
10.1126/science.abd4585
发表时间：
2020-10-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bastard P;Rosen LB;Zhang Q;Michailidis E;Hoffmann HH;Zhang Y;Dorgham K;Philippot Q;Rosain J;Béziat V;Manry J;Shaw E;Haljasmägi L;Peterson P;Lorenzo L;Bizien L;Trouillet-Assant S;Dobbs K;de Jesus AA;Belot A;Kallaste A;Catherinot E;Tandjaoui-Lambiotte Y;Le Pen J;Kerner G;Bigio B;Seeleuthner Y;Yang R;Bolze A;Spaan AN;Delmonte OM;Abers MS;Aiuti A;Casari G;Lampasona V;Piemonti L;Ciceri F;Bilguvar K;Lifton RP;Vasse M;Smadja DM;Migaud M;Hadjadj J;Terrier B;Duffy D;Quintana-Murci L;van de Beek D;Roussel L;Vinh DC;Tangye SG;Haerynck F;Dalmau D;Martinez-Picado J;Brodin P;Nussenzweig MC;Boisson-Dupuis S;Rodríguez-Gallego C;Vogt G;Mogensen TH;Oler AJ;Gu J;Burbelo PD;Cohen JI;Biondi A;Bettini LR;D'Angio M;Bonfanti P;Rossignol P;Mayaux J;Rieux-Laucat F;Husebye ES;Fusco F;Ursini MV;Imberti L;Sottini A;Paghera S;Quiros-Roldan E;Rossi C;Castagnoli R;Montagna D;Licari A;Marseglia GL;Duval X;Ghosn J;HGID Lab;NIAID-USUHS Immune Response to COVID Group;COVID Clinicians;COVID-STORM Clinicians;Imagine COVID Group;French COVID Cohort Study Group;Milieu Intérieur Consortium;CoV-Contact Cohort;Amsterdam UMC Covid-19 Biobank;COVID Human Genetic Effort;Tsang JS;Goldbach-Mansky R;Kisand K;Lionakis MS;Puel A;Zhang SY;Holland SM;Gorochov G;Jouanguy E;Rice CM;Cobat A;Notarangelo LD;Abel L;Su HC;Casanova JL
通讯作者：
Casanova JL
自动发芽中心的克隆进化。
影响因子：
64.5
作者：
Degn SE;van der Poel CE;Firl DJ;Ayoglu B;Al Qureshah FA;Bajic G;Mesin L;Reynaud CA;Weill JC;Utz PJ;Victora GD;Carroll MC
通讯作者：
Carroll MC
影响因子：
158.5
作者：
Arbuckle, MR;McClain, MT;Harley, JB
通讯作者：
Harley, JB