Dehydroepiandrosterone replacement in aging humans.
Dehydroepiandrosterone replacement in aging humans.
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老年人中的脱氢表雄酮替代品。
DOI：
10.1210/jcem.84.5.5672
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
G. Krause
中科院分区：
文献类型：
--
作者：
M. Flynn;D. Weaver;K. Sharpe;S. Allen;G. Krause
由于脱氢表雄酮（DHEA）及其硫酸酯（DHEAS）的益处引起了医学和媒体的广泛关注，因此采用双盲、交叉、随机研究方法客观评价替代治疗的效果是非常重要的。在这项为期9个月的研究中，健康的老年男性（n = 39）接受了替代剂量的DHEA。测量瘦体重、血液学、化学和内分泌值以及泌尿学和心理学数据。数据显示，与服用安慰剂3个月相比，口服100 mg DHEA 3个月期间发生了一些轻微和暂时但显著的变化。在6个月的治疗期间，身体成分没有变化，任何泌尿系统参数也没有变化。伴随着内分泌的变化，一些小的，但显着的变化，血液值（血尿素氮，肌酐，尿酸，丙氨酸转氨酶，胆固醇，高密度脂蛋白，钾）被发现后，停止DHEA和安慰剂，随后3个月的无治疗，所有的值先前被发现改变返回到进入基线。其他人报道的药物的广泛宣传效果，如幸福感或性功能改善，在这项研究中没有发现。
Because so much medical and media attention has been drawn to the alleged benefits of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS), it is important to evaluate the effects of replacement therapy objectively using double blind, cross-over, randomized research methodology. In this 9-month study, healthy older men (n = 39) received replacement dose DHEA. Lean body mass, blood hematology, chemistry and endocrine values, as well as urological and psychological data were measured. Data showed some mild and temporary, but significant, changes during oral use of 100 mg DHEA for 3 months compared with placebo taken for 3 months. Body composition did not change during the 6 months of treatment, nor did any urological parameters. Concomitant with the endocrine changes, some small but, significant, variations in blood values (blood urea nitrogen, creatinine, uric acid, alanine transaminase, cholesterol, high density lipoprotein, and potassium) were found. After cessation of DHEA and placebo, followed by 3 months of no treatment, all values previously found to be altered returned to entry baseline. Well publicized effects of the drug reported by others, such as a sense of well-being or improved sexual function, were not found in this study.
影响因子：
5.8
作者：
NESTLER, JE;BARLASCINI, CO;BLACKARD, WG
通讯作者：
BLACKARD, WG
正常女性中硫酸脱氢表雄酮 (DS) 的代谢清除率 (MCR)、其代谢为脱氢表雄酮、雄烯二酮、睾酮和二氢睾酮，以及血浆 DS 浓度升高对 DS MCR 的影响。
DOI：
10.1210/jcem-69-5-1047
发表时间：
1989
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
HaningJr,RV;Chabot,M;Flood,CA;Hackett,R;Longcope,C
通讯作者：
Longcope,C