Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects.
Hypoxia Induced Changes of Exosome Cargo and Subsequent Biological Effects.
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DOI：
10.3389/fimmu.2022.824188
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
外泌体是小的细胞外囊泡，其由几乎所有类型的细胞分泌并且存在于几乎所有细胞外间隙中。作为细胞间通讯的重要介质，外泌体将来自细胞质的miRNA、lncRNA、cirRNA、mRNA、细胞因子、酶、脂质和其他组分封装到其封闭的单膜结构中，并以自分泌、旁分泌或内分泌的方式将它们转移到受体单位。缺氧是一种低氧张力的状态，参与许多病理过程。缺氧影响外泌体货物的大小、数量和表达。来源于低氧肿瘤细胞的外泌体将遗传、蛋白质和脂质转移到受体单位以发挥多效性效应。不同的供体细胞产生不同的货物含量，靶向不同的受体单位，导致不同的生物学效应。来源于肿瘤细胞的低氧外泌体被含氧量正常的肿瘤细胞摄取，导致促进增殖、迁移和侵袭;被细胞外间隙或肝脏摄取，导致促进转移;被内皮细胞摄取，导致促进血管生成;被免疫细胞摄取，导致促进巨噬细胞极化，改变肿瘤免疫微环境。除了各种类型的肿瘤外，低氧外泌体还参与心血管系统、神经元系统、呼吸系统、血液系统、内分泌系统、泌尿系统、生殖系统和骨骼肌系统中疾病的发展。了解缺氧exosomes的特殊性为阐明缺氧相关疾病的发病机制提供了新的见解。本文综述了低氧诱导的货物变化以及低氧exosomes在不同系统肿瘤和非恶性疾病中的生物学效应。
Exosomes are small extracellular vesicles that are secreted by almost all types of cells and exist in almost all extracellular spaces. As an important mediator of intercellular communication, exosomes encapsulate the miRNA, lncRNA, cirRNA, mRNA, cytokine, enzyme, lipid, and other components from the cytoplasm into its closed single membrane structure and transfer them to recipient units in an autocrine, paracrine, or endocrine manner. Hypoxia is a state of low oxygen tension and is involved in many pathological processes. Hypoxia influences the size, quantity, and expression of exosome cargos. Exosomes derived from hypoxic tumor cells transfer genetics, proteins, and lipids to the recipient units to exert pleiotropic effects. Different donor cells produce different cargo contents, target different recipient units and lead to different biological effects. Hypoxic exosomes derived from tumor cells uptaken by normoxic tumor cells lead to promoted proliferation, migration, and invasion; uptaken by extracellular space or liver lead to promoted metastasis; uptaken by endothelial cells lead to promoted angiogenesis; uptaken by immune cells lead to promoted macrophage polarization and changed tumor immune microenvironment. In addition to various types of tumors, hypoxic exosomes also participate in the development of diseases in the cardiovascular system, neuron system, respiratory system, hematology system, endocrine system, urinary system, reproduction system, and skeletomuscular system. Understanding the special characteristics of hypoxic exosomes provide new insight into elaborating the pathogenesis of hypoxia related disease. This review summarizes hypoxia induced cargo changes and the biological effects of hypoxic exosomes in tumors and non-malignant diseases in different systems.
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DOI：
10.1038/mt.2008.1
发表时间：
2008-04
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
Dai S;Wei D;Wu Z;Zhou X;Wei X;Huang H;Li G
通讯作者：
Li G
DOI：
10.1007/s00018-014-1764-3
发表时间：
2015-02
期刊：
Cellular and molecular life sciences : CMLS
影响因子：
--
作者：
Brinton LT;Sloane HS;Kester M;Kelly KA
通讯作者：
Kelly KA
影响因子：
4.7
作者：
Chi Y;Xin H;Liu Z
通讯作者：
Liu Z
影响因子：
13.6
作者：
Borges, Fernanda T.;Melo, Sonia A.;Kalluri, Raghu
通讯作者：
Kalluri, Raghu
人骨髓间充质干细胞来源的细胞外囊泡促进大鼠心肌梗死模型中的血管生成
影响因子：
4.7
作者：
Bian, Suyan;Zhang, Liping;Yu, Hepeng
通讯作者：
Yu, Hepeng