One if by land, two if by sea: signalling to the ranks with CSP and XIP.
One if by land, two if by sea: signalling to the ranks with CSP and XIP.
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DOI:
10.1111/mmi.12029
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发表时间:
2012-10
影响因子:
3.6
通讯作者:
Morrison DA
中科院分区:
文献类型:
--
作者:
Federle MJ;Morrison DA
In many streptococci, quorum sensing utilizes secreted, linear peptides that engage cognate receptors to coordinate gene expression among members of a local population. Streptococcus mutans employs the secreted peptides CSP and XIP to stimulate production of antimicrobial bacteriocins and to induce development of competence for genetic transformation. Recent progress in the field reveals that pathways not only monitor the presence of signal emitters but also sense environmental factors. Both kinds of information are integrated by regulatory networks that then generate multiple outcomes, even among parallel cells growing in identical conditions. In this issue of Molecular Microbiology, Son and coworkers investigate how two medium types shape cellular responses to CSP and XIP pheromones in individuals across a population. Their findings characterize restrictive properties of media differing in peptidic fragment content and reveal unusual signaling properties that contribute to bimodal responses of gene expression.
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