One if by land, two if by sea: signalling to the ranks with CSP and XIP.

One if by land, two if by sea: signalling to the ranks with CSP and XIP.
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DOI:
10.1111/mmi.12029
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发表时间:
2012-10
影响因子:
3.6
通讯作者:
Morrison DA
Morrison DA
中科院分区:
生物学2区
文献类型:
--
作者:
Federle MJ;Morrison DA

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在许多链球菌中,群体感应利用分泌的线性肽参与同源受体来协调当地群体成员之间的基因表达。变形链球菌利用分泌的多肽CSP和XIP来刺激抗菌细菌素的产生,并诱导遗传转化能力的发展。该领域的最新进展表明,这些通路不仅可以监测信号发射器的存在,还可以感知环境因素。这两种信息通过调控网络整合在一起,然后产生多种结果,甚至在相同条件下生长的平行细胞之间也是如此。在本期的《分子微生物学》杂志上,Son和他的同事研究了两种培养基类型如何在一个群体中塑造个体对CSP和XIP信息素的细胞反应。他们的发现表征了不同多肽片段含量的介质的限制性特性,并揭示了导致基因表达双峰反应的不寻常的信号特性。
In many streptococci, quorum sensing utilizes secreted, linear peptides that engage cognate receptors to coordinate gene expression among members of a local population. Streptococcus mutans employs the secreted peptides CSP and XIP to stimulate production of antimicrobial bacteriocins and to induce development of competence for genetic transformation. Recent progress in the field reveals that pathways not only monitor the presence of signal emitters but also sense environmental factors. Both kinds of information are integrated by regulatory networks that then generate multiple outcomes, even among parallel cells growing in identical conditions. In this issue of Molecular Microbiology, Son and coworkers investigate how two medium types shape cellular responses to CSP and XIP pheromones in individuals across a population. Their findings characterize restrictive properties of media differing in peptidic fragment content and reveal unusual signaling properties that contribute to bimodal responses of gene expression.
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