Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants.
Evaluation of genetic variability in the dopamine receptor D2 in relation to behavioral inhibition and impulsivity/sensation seeking: an exploratory study with d-amphetamine in healthy participants.
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DOI：
10.1037/a0017840
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发表时间：
2009-12
影响因子：
2.3
通讯作者：
de Wit H
中科院分区：
文献类型：
--
作者：
Hamidovic A;Dlugos A;Skol A;Palmer AA;de Wit H
多巴胺D2受体（DRD 2）似乎参与冲动行为，特别是行为抑制。我们试图确定抑制和冲动是否与健康志愿者（N = 93）的DRD 2基因（DRD 2）的遗传多态性有关。参与者随机接受安慰剂或d-安非他明。他们执行停止任务，测量行为抑制，并在每次会议上评估他们的情绪状态。他们还完成了Zuckerman-Kuhlman人格问卷，包括冲动子量表。我们研究了12个单核苷酸多态性（SNP）和DRD 2单倍型与非药物（即，安慰剂）会议和冲动性的人格测量。我们第二次评估DRD 2单核苷酸多态性与对d-苯丙胺停止任务表现和情绪评级的反应。情绪是不相关的基因型，无论是在药物自由的条件下，或对药物的反应。然而，2个SNPs，rs 4648317和rs 12364283，以及由这些SNPs组成的单倍型块，与无药物条件下停止任务的更好表现和冲动子量表的较低得分相关。我们还发现rs 12364283与d-苯丙胺对停止任务表现的影响有关：d-苯丙胺降低了A/A组的停止反应时间（RT），但增加了A/G + G/G基因型的停止RT。在我们评估的SNPs中，与DRD 2表达相关的rs 12364283与抑制和冲动相关性最显著。DRD 2基因型与行为抑制和冲动之间的显着关系表明，冲动的行为和自我报告措施可能有共同的遗传影响。
The dopamine D2 receptor (DRD2) appears to be involved in impulsive behaviors, and particularly in behavioral inhibition. We sought to determine whether inhibition and impulsivity were related to genetic polymorphisms in the DRD2 gene (DRD2) in healthy volunteers (N = 93). Participants received placebo or d-amphetamine in random order. They performed the stop task, measuring behavioral inhibition, and rated their mood states on each session. They also completed the Zuckerman–Kuhlman Personality Questionnaire, including an Impulsivity subscale. We investigated the association between 12 single nucleotide polymorphisms (SNPs) and haplotypes in DRD2 and stop task performance in the nondrug (i.e., placebo) session and on the personality measure of impulsivity. We secondarily evaluated the DRD2 SNPs in relation to response to d-amphetamine on stop task performance and mood ratings. Mood was not related to genotypes in either the drug free condition or in response to drug. However, 2 SNPs, rs4648317 and rs12364283, and a haplotype block consisting of those SNPs, were associated with better performance on the stop task in the drug free condition and lower scores on the Impulsivity subscale. We also found that rs12364283 was associated with effects of d-amphetamine on stop task performance: d-amphetamine decreased stop reaction time (RT) in the A/A group but increased stop RT in the combined A/G + G/G genotype. Of the SNPs we evaluated, rs12364283, which has been associated with DRD2 expression, was the most significantly associated with inhibition and impulsivity. The significant relationship between DRD2 genotype and both behavioral inhibition and impulsivity suggests a possible common genetic influence on behavioral and self-report measures of impulsivity.
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