Nematode-trapping fungi eavesdrop on nematode pheromones.

Nematode-trapping fungi eavesdrop on nematode pheromones.
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DOI:
10.1016/j.cub.2012.11.035
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发表时间:
2013-01-07
期刊:
影响因子:
9.2
通讯作者:
Sternberg, Paul W.
Sternberg, Paul W.
中科院分区:
生物学1区
文献类型:
--
作者:
Hsueh, Yen-Ping;Mahanti, Parag;Schroeder, Frank C.;Sternberg, Paul W.

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识别与特定病原体或食物来源相关的分子模式是生态学的基础,在捕食者-猎物关系的进化中起着重要作用。最近的研究表明,线虫产生一个进化上高度保守的小分子家族,即蛔虫苷,其在调节线虫发育和行为中起重要作用。在这里,我们表明,食腐真菌,土壤中的线虫的天敌,可以检测和响应阿沙洛苷。食线虫真菌使用专门的诱捕装置捕捉和消耗线虫,以前的研究表明,大多数真菌物种不产生陷阱组成,而是启动陷阱形成,以应对他们的猎物。我们发现,Ascarosides,这是组成分泌的许多物种的土壤中居住的线虫,代表了一个保守的分子模式用于食草真菌检测猎物和触发陷阱的形成。在几种密切相关的食草真菌中,只有在营养缺乏的条件下,才会发生Ascaroside诱导的形态发生。我们的研究结果表明,微生物捕食者窃听化学通讯之间的后生动物的猎物,以调节形态发生,提供了一个引人注目的例子捕食者-猎物的共同进化。我们预计,这些发现将对理解涉及线虫的其他王国间相互作用产生更广泛的影响,这些线虫几乎存在于地球上的任何生态位中。
The recognition of molecular patterns associated with specific pathogens or food sources is fundamental to ecology and plays a major role in the evolution of predator-prey relationships. Recent studies showed that nematodes produce an evolutionarily highly conserved family of small molecules, the ascarosides, which serve essential functions in regulating nematode development and behavior. Here we show that nematophagous fungi, natural predators of soil-dwelling nematodes, can detect and respond to ascarosides. Nematophagous fungi use specialized trapping devices to catch and consume nematodes, and previous studies demonstrated that most fungal species do not produce traps constitutively but rather initiate trap-formation in response to their prey. We found that ascarosides, which are constitutively secreted by many species of soil-dwelling nematodes, represent a conserved molecular pattern used by nematophagous fungi to detect prey and trigger trap formation. Ascaroside-induced morphogenesis is conserved in several closely related species of nematophagous fungi and occurs only under nutrient-deprived condition. Our results demonstrate that microbial predators eavesdrop on chemical communication among their metazoan prey to regulate morphogenesis, providing a striking example of predator-prey co-evolution. We anticipate that these findings will have broader implications for understanding other inter-kingdom interactions involving nematodes, which are found in almost any ecological niche on Earth.
比较代谢组学揭示了丙烷剂的生物发生,这是秀丽隐杆线虫中小分子信号的模块化库。
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