Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders.
Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders.
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DOI：
10.1021/acs.jnatprod.5b00225
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发表时间：
2015-11-25
影响因子：
5.1
通讯作者：
Wei L
中科院分区：
文献类型：
--
作者：
Woodbury A;Yu SP;Chen D;Gu X;Lee JH;Zhang J;Espinera A;García PS;Wei L
这项研究检测了和厚朴酚(一种从木兰花中分离出来的自然产生的木脂素)对暴露于炎性疼痛中的新生儿大脑发育的短期和长期神经保护和镇痛活性，炎性疼痛已知会导致神经细胞死亡。新生大鼠出生后第4天(P4)，足底注射福尔马林4只，造成严重的新生儿疼痛模型。福尔马林损毁前1h腹腔注射和厚朴酚(10 mg/kg)或玉米油载体剂对照，连续给药至出生后第21天(P21)。在痛苦的侮辱后，进行了应激和疼痛的行为测试，随后对P7和P21的脑切片进行了形态检查。和厚朴酚显著减轻福尔马林伤害后30分钟的急性疼痛反应，并减少以后生活中的慢性热痛敏。和厚朴酚处理的大鼠在探索行为测试中表现更好，在记忆测试中表现明显更好。与对照组相比，和厚朴酚治疗在P21时使海马和丘脑c-Fos和海马肺泡P物质受体的表达正常化。综上所述，这些发现支持：(1)新生儿疼痛体验使大鼠容易发生慢性行为变化，(2)和厚朴酚预防和减轻新生大鼠急性和慢性病理性疼痛诱导的恶化。
This study examined the short- and long-term neuroprotective and analgesic activity of honokiol (a naturally occurring lignan isolated from Magnolia) on developing brains in neonates exposed to inflammatory pain, known to cause neuronal cell death. Postnatal day 4 (P4) neonatal rat pups were subjected to intraplantar formalin injection to four paws as a model of severe neonatal pain. Intraperitoneal honokiol (10 mg/kg) or corn oil vehicle control was administered 1 h prior to formalin insult, and animals were maintained on honokiol through postnatal day 21 (P21). Behavioral tests for stress and pain were performed after the painful insult, followed by morphological examinations of the brain sections at P7 and P21. Honokiol significantly attenuated acute pain responses 30 min following formalin insult and decreased chronic thermal hyperalgesia later in life. Honokiol-treated rats performed better on tests of exploratory behavior and performed significantly better in tests of memory. Honokiol treatment normalized hippocampal and thalamic c-Fos and hippocampal alveus substance P receptor expression relative to controls at P21. Together, these findings support that (1) neonatal pain experiences predispose rats to the development of chronic behavioral changes and (2) honokiol prevents and reduces both acute and chronic pathological pain-induced deteriorations in neonatal rats.
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影响因子：
2.5
作者：
Duehrsen, Lasse;Simons, Sinno H. P.;Felderhoff-Mueser, Ursula
通讯作者：
Felderhoff-Mueser, Ursula
影响因子：
7.4
作者：
Jarcho JM;Feier NA;Bert A;Labus JA;Lee M;Stains J;Ebrat B;Groman SM;Tillisch K;Brody AL;London ED;Mandelkern MA;Mayer EA
通讯作者：
Mayer EA
影响因子：
5
作者：
Liou, KT;Shen, YC;Tsai, SK
通讯作者：
Tsai, SK
影响因子：
3.3
作者：
Duric, V;McCarson, KE
通讯作者：
McCarson, KE
影响因子：
2.7
作者：
Fukuyama, Y;Nakade, K;Mitsumoto, Y
通讯作者：
Mitsumoto, Y