The miR-181 family: Wide-ranging pathophysiological effects on cell fate and function.
The miR-181 family: Wide-ranging pathophysiological effects on cell fate and function.
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DOI：
10.1002/jcp.30969
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发表时间：
2023-04
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
microRNA（miRNAs）是表观遗传调节因子，其可以靶向并抑制给定细胞类型内的多种mRNA的翻译。因此，许多不同的途径和网络可以作为结果被调节。事实上，已知miRNA调节许多细胞过程，包括分化、增殖、炎症和代谢。本文综述了miR-181家族，并从已发表的文献中提供了有关miR-181同源物在调节不同细胞类型和组织中的一系列活动中的作用的信息。值得注意的是，我们没有包括癌症背景下miR-181表达和功能的详细信息，因为这是一个需要独立审查的广泛主题领域。相反，我们专注于描述miR-181家族成员在各种非肿瘤条件下向许多细胞谱系（例如免疫/造血细胞、成骨细胞、破骨细胞、软骨细胞、脂肪细胞）分化的功能和机制。我们还提供了关于调节miR-181同源物如何对疾病状态如心脏异常、肺动脉高压、血栓形成、骨关节炎和血管炎症产生积极影响的信息。在这种情况下，我们使用了一些FDA批准的调节miR-181表达的药物。最后，我们讨论了一些常见的机制，通过这些机制，miR-181同源物似乎可以调节许多不同的细胞过程，以及靶向特定的miR-181家族成员如何可能导致有吸引力的治疗方法来治疗许多人类疾病或修复条件，包括与衰老过程相关的疾病或修复条件。
MicroRNAs (miRNAs) are epigenetic regulators that can target and inhibit translation of multiple mRNAs within a given cell type. As such, a number of different pathways and networks may be modulated as a result. In fact, miRNAs are known to regulate many cellular processes including differentiation, proliferation, inflammation and metabolism. This review focuses on the miR-181 family and provides information from the published literature on the role of miR-181 homologs in regulating a range of activities in different cell types and tissues. Of note, we have not included details on miR-181 expression and function in the context of cancer since this is a broad topic area requiring independent review. Instead, we have focused on describing the function and mechanism of miR-181 family members on differentiation toward a number of cell lineages in various non-neoplastic conditions (e.g. immune/hematopoietic cells, osteoblasts, osteoclasts, chondrocytes, adipocytes). We have also provided information on how modulation of miR-181 homologs can have positive effects on disease states such as cardiac abnormalities, pulmonary arterial hypertension, thrombosis, osteoarthritis and vascular inflammation. In this context, we have used some examples of FDA-approved drugs that modulate miR-181 expression. We conclude by discussing some common mechanisms by which miR-181 homologs appear to regulate a number of different cellular processes and how targeting specific miR-181 family members may lead to attractive therapeutic approaches to treat a number of human disease or repair conditions, including those associated with the aging process.
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影响因子：
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作者：
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DOI：
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发表时间：
2015-11
期刊：
Stem cells (Dayton, Ohio)
影响因子：
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作者：
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通讯作者：
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影响因子：
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