Ultrastructural analysis of the cristae ampullares in the squirrel monkey (Saimiri sciureus).

Ultrastructural analysis of the cristae ampullares in the squirrel monkey (Saimiri sciureus).
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DOI:
10.1002/cne.21827
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发表时间:
2008-11-01
影响因子:
2.5
通讯作者:
Goldberg, Jay M.
Goldberg, Jay M.
中科院分区:
医学3区
文献类型:
--
作者:
Lysakowski, Anna;Goldberg, Jay M.

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松鼠猴 (Saimiri sciureus) 嵴中 I 型毛细胞的数量多于 II 型毛细胞 (HC),比例接近 3:1。与这种 I 型 HC 优势相关,萼纤维在传入神经支配中所占的比例比啮齿类动物大得多。为了研究这如何影响突触结构,我们使用解剖器方法来估计与猴嵴中央(CZ)和外周(PZ)区域中的 I 型和 II 型 HC 相关的各种特征。每个 I 型 HC 平均会在花萼末端的内表面形成 5-10 个带状突触。内面突触数量多于花萼外表面突触数量,比例为 40:1。以每个传入神经表示,在萼轴承末端平均有 15 个内面带状突触、0.38 个外面带状突触和 2.6 个传出突触。每个 I 型 HC 的肾盏内陷范围为 CZ 中的 19 个到 PZ 中的 3 个。对于 II 型 HC,PZ 中的丝带和传入神经支配比 CZ 中多得多,而传出神经支配在整个神经上皮中相对均匀。尽管龙猫的外表面带比松鼠猴的数量更多,但传入放电特性相似,这增强了内表面带在突触传递中的重要性。跨哺乳动物物种的比较表明,I 型 HC 的流行是灵长类动物的特征,而不是树栖生活方式的适应。与嵴不同,II 型 HC 在猴斑中占主导地位。毛细胞计数的差异可能反映了半规管和耳石器官处理的刺激强度。
Type I hair cells outnumber type II hair cells (HCs) in squirrel monkey (Saimiri sciureus) cristae by a nearly 3:1 ratio. Associated with this type I HC preponderance, calyx fibers make up a much larger fraction of the afferent innervation than in rodents. To study how this affected synaptic architecture, we used disector methods to estimate various features associated with type I and type II HCs in central (CZ) and peripheral (PZ) zones of monkey cristae. Each type I HC makes, on average, 5–10 ribbon synapses with the inner face of a calyx ending. Inner-face synapses outnumber those on calyx outer faces by a 40:1 ratio. Expressed per afferent, there are, on average, 15 inner-face ribbon synapses, 0.38 outer-face ribbons and 2.6 efferent boutons on calyx-bearing endings. Calyceal invaginations per type I HC range from 19 in CZ to 3 in PZ. For type II HCs, there are many more ribbons and afferent boutons in PZ than in CZ, whereas efferent innervation is relatively uniform throughout the neuroepithelium. Despite outer-face ribbons being more numerous in chinchilla than in squirrel monkey, afferent discharge properties are similar, reinforcing the importance of inner-face ribbons in synaptic transmission. Comparisons across mammalian species suggest the prevalence of type I HCs is a primate characteristic, rather than an arboreal lifestyle adaptation. Unlike cristae, type II HCs predominate in monkey maculae. Differences in hair-cell counts may reflect the stimulus magnitudes handled by semicircular canals and otolith organs.
DOI: 10.1152/jn.1988.60.1.167
发表时间: 1988-07-01
影响因子: 2.5
作者:
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通讯作者: GOLDBERG, JM
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发表时间: 2000-03-01
影响因子: 2.5
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通讯作者: Goldberg, JM
DOI: 10.1152/jn.00771.2001
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影响因子: 2.5
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通讯作者: Brichta, AM
DOI: 10.1152/jn.1988.60.1.182
发表时间: 1988-07-01
影响因子: 2.5
作者:
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通讯作者: GOLDBERG, JM
DOI: 10.1073/pnas.0405260101
发表时间: 2004-12-21
影响因子: 11.1
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通讯作者: McGuire, JA