Eicosanoid signaling in carcinogenesis of colorectal cancer.
Eicosanoid signaling in carcinogenesis of colorectal cancer.
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DOI：
10.1007/s10555-018-9739-8
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Zhang G
中科院分区：
文献类型：
--
作者：
Wang Y;Wang W;Sanidad KZ;Shih PA;Zhao X;Zhang G
结直肠癌 (CRC) 是美国第三大常见癌症，也是癌症相关死亡的第二大原因。确定结直肠癌的新治疗靶点以开发新的抗癌药物，发现结直肠癌的新生物标志物以开发新的检测方法具有重要的现实意义。类二十烷酸是环氧合酶 (COX)、脂氧合酶 (LOX) 和细胞色素 P450 (CYP) 酶产生的多不饱和脂肪酸的代谢产物，是参与炎症和肿瘤发生调节的重要脂质信号分子。大量研究表明，类二十烷酸的分布在结直肠癌中失调，类二十烷酸信号级联中的酶、代谢物和受体在调节结肠炎症和结肠肿瘤发生中发挥着关键作用。 In this review, we discuss the roles of the COX, LOX, and CYP pathways in the carcinogenesis of CRC.
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related death in the United States. It is of practical importance to identify novel therapeutic targets of CRC to develop new anti-cancer drugs, and to discover novel biomarkers of CRC to develop new detection methods. Eicosanoids, which are metabolites of polyunsaturated fatty acids produced by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes, are important lipid signaling molecules involved in the regulation of inflammation and tumorigenesis. Substantial studies have shown that the profiles of eicosanoids are deregulated in CRC, and the enzymes, metabolites, and receptors in the eicosanoid signaling cascade play critical roles in regulating colonic inflammation and colon tumorigenesis. In this review, we discuss the roles of the COX, LOX, and CYP pathways in the carcinogenesis of CRC.
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影响因子：
3.7
作者：
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Donnini S
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影响因子：
56.9
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影响因子：
3.2
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