Antibodies to citrullinated protein antigens (ACPAs): clinical and pathophysiologic significance.
Antibodies to citrullinated protein antigens (ACPAs): clinical and pathophysiologic significance.
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DOI：
10.1007/s11926-011-0193-7
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发表时间：
2011-10
影响因子：
5
通讯作者：
Deane, Kevin
中科院分区：
文献类型：
--
作者：
Demoruelle, M. Kristen;Deane, Kevin
关键词：
瓜氨酸蛋白抗原 (ACPA) 抗体对类风湿性关节炎 (RA) 具有高度特异性，可用于诊断 RA 以及预测疾病的病程和结果。存在多种测量 ACPA 的方法，包括广泛使用的抗环瓜氨酸肽抗体和突变/修饰瓜氨酸波形蛋白抗体测试。尽管存在一些差异，但这些方法总体上对 RA 具有相似的诊断准确性。 ACPA 的发现和瓜氨酸化生物学也促进了对 RA 病理生理学和发展的理解的重要进展，特别是在 RA 潜在遗传和环境危险因素之间的关系方面。展望未来，对瓜氨酸蛋白自身免疫的研究可能有助于确定 RA 的具体病因，并为预测未来疾病风险并最终预防 RA 提供方法。
Antibodies to citrullinated protein antigens (ACPAs) are highly specific for rheumatoid arthritis (RA) and are useful in the diagnosis of RA as well as the prediction of the course and outcomes of disease. Multiple methodologies exist for measuring ACPAs, including the widely available tests for anticyclic citrullinated peptide antibodies and for antibodies to mutated/modified citrullinated vimentin. These methodologies overall have similar diagnostic accuracies for RA, although there is some variability. The discovery of ACPAs and the biology of citrullination have also led to important advances in the understanding of the pathophysiology and development of RA, especially regarding the relationship between potential genetic and environmental risk factors for RA. Going forward, research into autoimmunity to citrullinated proteins may help identify the specific etiology of RA and provide approaches for the prediction of future risk of disease, and ultimately prevention of RA.
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