Vaccination from the early second trimester onwards gives a robust SARS-CoV-2 antibody response throughout pregnancy and provides antibodies for the neonate.
Vaccination from the early second trimester onwards gives a robust SARS-CoV-2 antibody response throughout pregnancy and provides antibodies for the neonate.
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DOI：
10.1016/j.ijid.2023.02.022
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发表时间：
2023-05
影响因子：
8.4
通讯作者：
van Leeuwen, Elisabeth
中科院分区：
文献类型：
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作者：
Zilver, Sanne J. M.;de Groot, Christianne J. M.;Grobben, Marloes;Remmelzwaal, Sharon;Burgers, Esmee;Velasco, Daniela Nunez;Juncker, Hannah G.;van Keulen, Britt J.;van Goudoever, Johannes B.;de Leeuw, Robert A.;van Gils, Marit J.;Ris-Stalpers, Carrie;van Leeuwen, Elisabeth
预防COVID-19对孕妇至关重要。孕妇由于生理变化，特别容易受到新出现的传染性病原体的影响。我们旨在确定接种疫苗的最佳时间，以保护孕妇及其新生儿免受COVID-19的影响。在接受COVID-19疫苗接种的孕妇中进行的前瞻性观察性纵向队列研究。我们在接种前和第一次和第二次接种后15天采集血液样本，以评估抗SARS-CoV-2的抗刺突抗体、受体结合结构域抗体和核衣壳抗体的水平。我们测定了出生时母血和脐带血中母婴二对体的中和抗体。如可用，测量人乳中的免疫球蛋白A。178名孕妇。中位抗刺突免疫球蛋白G水平从1.8显著增加至5431结合抗体单位/ml，受体结合域从6显著增加至4466结合抗体单位/ml。接种时不同孕周的病毒中和结果相似（P >0.3）。我们建议在妊娠中期早期接种疫苗，以便在母体抗体反应和胎盘抗体转移到新生儿之间达到最佳平衡。
Preventive measures against COVID-19 are essential for pregnant women. Pregnant women are particularly vulnerable to emerging infectious pathogens due to alterations in their physiology. We aimed to determine the optimum timing of vaccination to protect pregnant women and their neonates from COVID-19. A prospective observational longitudinal cohort study in pregnant women who received COVID-19 vaccination. We collected blood samples to evaluate levels of antispike, receptor binding domain and nucleocapsid antibodies against SARS-CoV-2 before vaccination and 15 days after the first and second vaccination. We determined the neutralizing antibodies from mother-infant dyads in maternal and umbilical cord blood at birth. If available, immunoglobulin A was measured in human milk. We included 178 pregnant women. Median antispike immunoglobulin G levels increased significantly from 1.8 to 5431 binding antibody units/ml and receptor binding domain from 6 to 4466 binding antibody units/ml. Virus neutralization showed similar results between different weeks of gestation at vaccination (P >0.3). We advise vaccination in the early second trimester of pregnancy for the optimum balance between the maternal antibody response and placental antibody transfer to the neonate.
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影响因子：
--
作者：
Palmeira P;Quinello C;Silveira-Lessa AL;Zago CA;Carneiro-Sampaio M
通讯作者：
Carneiro-Sampaio M
影响因子：
4.3
作者：
Collin, Julius;Bystrom, Emma;Ahrne, Malin
通讯作者：
Ahrne, Malin
影响因子：
13.8
作者：
Edlow AG;Li JZ;Collier AY;Atyeo C;James KE;Boatin AA;Gray KJ;Bordt EA;Shook LL;Yonker LM;Fasano A;Diouf K;Croul N;Devane S;Yockey LJ;Lima R;Shui J;Matute JD;Lerou PH;Akinwunmi BO;Schmidt A;Feldman J;Hauser BM;Caradonna TM;De la Flor D;D'Avino P;Regan J;Corry H;Coxen K;Fajnzylber J;Pepin D;Seaman MS;Barouch DH;Walker BD;Yu XG;Kaimal AJ;Roberts DJ;Alter G
通讯作者：
Alter G
怀孕期间接种 COVID-19 疫苗：覆盖范围和安全性。
影响因子：
9.8
作者：
Blakeway H;Prasad S;Kalafat E;Heath PT;Ladhani SN;Le Doare K;Magee LA;O'Brien P;Rezvani A;von Dadelszen P;Khalil A
通讯作者：
Khalil A
影响因子：
9.8
作者：
DeBolt CA;Bianco A;Limaye MA;Silverstein J;Penfield CA;Roman AS;Rosenberg HM;Ferrara L;Lambert C;Khoury R;Bernstein PS;Burd J;Berghella V;Kaplowitz E;Overbey JR;Stone J
通讯作者：
Stone J