Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression.
Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression.
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DOI：
10.1007/s12035-013-8422-x
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发表时间：
2013-08
影响因子：
5.1
通讯作者：
Pinto, Luisa
中科院分区：
文献类型：
--
作者：
Patricio, Patricia;Mateus-Pinheiro, Antonio;Sousa, Nuno;Pinto, Luisa
自从成人神经发生成为一种被广泛接受的现象以来，人们一直在努力了解其调控机制。此外，一些神经精神疾病的病理生理学，如抑郁症，已与成人海马神经发生的不平衡。这些不平衡可能最终反映了细胞周期水平的改变，作为一种常见的机制，通过这种机制，内在和外在的刺激与神经原性生态位特性相互作用。因此，理解这些调控机制对于揭示新的治疗靶点具有重要意义。在这篇综述中，我们首先提出了一个全面的观点，在稳态成人海马神经原生态位的背景下确定的细胞周期成分和机制。然后，我们专注于最近的工作，对细胞周期的变化和信号通路，负责观察到的神经病理条件下的神经发生不平衡，特别强调抑郁症。
Since adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been associated with imbalances in adult hippocampal neurogenesis. These imbalances may ultimately reflect alterations at the cell cycle level, as a common mechanism through which intrinsic and extrinsic stimuli interact with the neurogenic niche properties. Thus, the comprehension of these regulatory mechanisms has become of major importance to disclose novel therapeutic targets. In this review, we first present a comprehensive view on the cell cycle components and mechanisms that were identified in the context of the homeostatic adult hippocampal neurogenic niche. Then, we focus on recent work regarding the cell cycle changes and signaling pathways that are responsible for the neurogenesis imbalances observed in neuropathological conditions, with a particular emphasis on depression.
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影响因子：
11
作者：
Bessa, J. M.;Ferreira, D.;Sousa, N.
通讯作者：
Sousa, N.
影响因子：
8.2
作者：
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3.5
作者：
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5.3
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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