TASK-2: a K2P K(+) channel with complex regulation and diverse physiological functions.
TASK-2: a K2P K(+) channel with complex regulation and diverse physiological functions.
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DOI：
10.3389/fphys.2013.00198
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发表时间：
2013
影响因子：
4
通讯作者：
Sepúlveda FV
中科院分区：
文献类型：
--
作者：
Cid LP;Roa-Rojas HA;Niemeyer MI;González W;Araki M;Araki K;Sepúlveda FV
TASK-2 （K2P5.1）是一个双孔结构域的K+通道，属于K2P蛋白家族的TALK亚群。TASK-2已被证明可被细胞外和细胞内碱化激活。胞外和胞内ph传感器位于精氨酸224和赖氨酸245，可能分别影响单独的选择性过滤器和内门。TASK-2受细胞体积变化的调节，也有人提出直接g蛋白相互作用的调节。细胞外碱化激活与TASK-2在肾近端小管碳酸氢盐重吸收中的作用有关，而细胞内ph敏感性可能是其参与中枢化学敏感神经元的机制。除了这些功能外，TASK-2还被认为在肾细胞凋亡体积减少以及神经胶质细胞和t淋巴细胞的体积调节中发挥作用。TASK-2存在于透明软骨的软骨细胞中，被认为在稳定膜电位中起核心作用。其他表达位点为背根神经节神经元、内分泌和外分泌胰腺和肠平滑肌细胞。TASK-2与乳腺癌细胞增殖的调控有关，可能成为乳腺癌治疗的靶点。对原生组织和细胞的进一步研究，加上基因改造，无疑将揭示出我们刚刚开始怀疑的TASK-2功能的细节。
TASK-2 (K2P5.1) is a two-pore domain K+ channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinization. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate selectivity filter and inner gates respectively. TASK-2 is modulated by changes in cell volume and a regulation by direct G-protein interaction has also been proposed. Activation by extracellular alkalinization has been associated with a role of TASK-2 in kidney proximal tubule bicarbonate reabsorption, whilst intracellular pH-sensitivity might be the mechanism for its participation in central chemosensitive neurons. In addition to these functions TASK-2 has been proposed to play a part in apoptotic volume decrease in kidney cells and in volume regulation of glial cells and T-lymphocytes. TASK-2 is present in chondrocytes of hyaline cartilage, where it is proposed to play a central role in stabilizing the membrane potential. Additional sites of expression are dorsal root ganglion neurons, endocrine and exocrine pancreas and intestinal smooth muscle cells. TASK-2 has been associated with the regulation of proliferation of breast cancer cells and could become target for breast cancer therapeutics. Further work in native tissues and cells together with genetic modification will no doubt reveal the details of TASK-2 functions that we are only starting to suspect.
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影响因子：
56.9
作者：
Doyle, DA;Cabral, JM;MacKinnon, R
通讯作者：
MacKinnon, R
影响因子：
3.4
作者：
Bobak, Nicole;Bittner, Stefan;Sukhorukov, Vladimir L.
通讯作者：
Sukhorukov, Vladimir L.
影响因子：
--
作者：
DAVIS, BA;HOGAN, EM;BORON, WF
通讯作者：
BORON, WF
DOI：
10.1007/s00249-009-0457-6
发表时间：
2009-12-01
影响因子：
2
作者：
Cohen, Asi;Ben-Abu, Yuval;Zilberberg, Noam
通讯作者：
Zilberberg, Noam
DOI：
10.1098/rstb.2009.0085
发表时间：
2009-09-12
影响因子：
6.3
作者：
Dubreuil, Veronique;Barhanin, Jacques;Brunet, Jean-Francois
通讯作者：
Brunet, Jean-Francois