Diagnosis and treatment of patients with nonacid gastroesophageal reflux-induced chronic cough.
Diagnosis and treatment of patients with nonacid gastroesophageal reflux-induced chronic cough.
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非酸性胃食管反流性慢性咳嗽的诊治
DOI：
10.4103/1735-1995.170625
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Qiu Z
中科院分区：
文献类型：
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作者：
Xu X;Yu L;Chen Q;Lv H;Qiu Z
胃食道反流(GER)是慢性咳嗽最常见的原因之一，由GER引起的慢性咳嗽是GER相关疾病的一个亚型。胃食道反流性慢性咳嗽(GERC)可根据胃食道反流性慢性咳嗽的pH值分为两个亚型。非酸性GERC较酸性GERC少见，其诊断和治疗策略尚不规范。然而，在临床诊断和治疗时，非酸性细菌通常会表现出一套独特的特征和特点。虽然非酸性GERC的分子机制还不完全清楚，但它被认为与反流理论、反射理论和呼吸道超敏反应有关。多通道腔内阻抗结合pH监测是一种很有前途的新技术，可以同时检测酸和非酸反流，我们的研究结果以及其他人的研究结果表明，它在诊断非酸性细菌方面是有用的。新诊断技术的发展提高了非酸性细菌的诊断率。我们总结了非酸性细菌的诊断和治疗经验，并为今后的治疗方法提供指导。
Gastroesophageal reflux (GER) is one of the most common causes of chronic cough, and chronic cough due to GER represents a subtype of GER-related diseases. Gastroesophageal reflux-induced chronic cough (GERC) can be divided into two subgroups based on the pH of the GER. Nonacid GERC is less common than acid GERC, and its diagnosis and treatment strategy have not been standardized. However, nonacid GERC usually presents with its unique set of characteristics and features upon diagnosis and treatment in the clinic. Although the underlying molecular mechanism of nonacid GERC is not fully understood, it is considered to be associated with reflux theory, reflex theory and airway hypersensitivity. Multi-channel intraluminal impedance combined with pH monitoring is a promising new technique that can detect both acid and nonacid reflux, and our findings as well as those of others have shown its usefulness in diagnosing nonacid GERC. Development of new diagnostic techniques has led to an increased rate of nonacid GERC diagnosis. We summarize our experience in the diagnosis and treatment of nonacid GERC and provide a guide for future therapeutic approaches.
奥美拉唑对胃食管反流咳嗽时呼出气冷凝物的 pH 值没有影响。
DOI：
10.1186/1745-9974-1-10
发表时间：
2005-10-19
期刊：
Cough (London, England)
影响因子：
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作者：
Torrego A;Cimbollek S;Hew M;Chung KF
通讯作者：
Chung KF