The epigenome as a potential mediator of cancer and disease prevention in prenatal development.
The epigenome as a potential mediator of cancer and disease prevention in prenatal development.
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表观基因组是产前发育中癌症和疾病预防的潜在介体。
DOI：
10.1111/nure.12030
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发表时间：
2013-07
影响因子：
6.1
通讯作者：
Williams DE
中科院分区：
文献类型：
--
作者：
Kaur P;Shorey LE;Ho E;Dashwood RH;Williams DE
表观遗传学事件在分化和受精过程中为每种细胞类型建立了特定的基因表达特征。在产前暴露于环境刺激时，这些表观遗传程序的中断会扰乱胎儿的表观基因组，潜在地影响以后的生命对疾病的易感性(成人疾病的胎儿基础)。孕妇在妊娠期和哺乳期的饮食调整在胎儿(再)计划阶段起着关键作用。近年来，许多研究证实了母体营养对胎儿表观基因组的影响。在这篇综述中，我们讨论了影响人类和动物模型的各种环境因素和表观遗传机制之间的复杂相互作用。我们在这里总结了各种能够调节表观基因组的饮食植物化学物质在不同的人类癌症和具有潜在环境病因的儿童癌症中的影响，这些影响通过孕期和哺乳期的母体摄入来实现，并讨论了其他仍未测试其在经胎盘研究中的有效性的饮食制剂。这里讨论的最新进展加深了我们对化学预防药物如何作用的理解，它们对产前表观基因组的潜在影响，以及确定在治疗和预防疾病方面有益的饮食干预措施。
Epigenetic events establish a particular gene expression signature for each cell type during differentiation and fertilization. Disruption of these epigenetic programs in response to environmental stimuli during prenatal exposure dysregulates the fetal epigenome, potentially impacting susceptibility to disease later in life (the fetal basis of adult disease). Maternal dietary modifications during gestation and lactation play a pivotal role in the period of fetal (re)programming. Recently, many studies have demonstrated the impact of maternal nutrition on the fetal epigenome. In this review, we discuss the complex interplay between various environmental factors and epigenetic mechanisms which have been found to affect the human and animal models. We summarize here the impact of various dietary phytochemicals capable of modulating the epigenome in diverse human cancers and childhood cancer with potential environmental etiology through maternal consumption during pregnancy and lactation and discuss other dietary agents that are still untested as to their effectiveness in transplacental studies. Recent developments discussed here enhance our understanding of how chemopreventive agents act, their potential to impact the prenatal epigenome and to identify dietary interventions that can be beneficial in treating and preventing disease.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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