Fatty liver in men is associated with high serum levels of small, dense low-density lipoprotein cholesterol.
Fatty liver in men is associated with high serum levels of small, dense low-density lipoprotein cholesterol.
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DOI：
10.1186/1758-5996-4-34
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发表时间：
2012-07-18
影响因子：
4.8
通讯作者：
Tsubouchi H
中科院分区：
文献类型：
--
作者：
Hosoyamada K;Uto H;Imamura Y;Hiramine Y;Toyokura E;Hidaka Y;Kuwahara T;Kusano K;Saito K;Oketani M;Ido A;Tsubouchi H
Our study addressed potential associations between fatty liver and small, dense low-density lipoprotein cholesterol (sd-LDL-C) levels using a cross-sectional analysis. We enrolled 476 male subjects. Serum sd-LDL-C concentrations were determined using precipitation assays. Subjects were divided into four groups based on triglyceride (TG) and LDL-C levels: A, TG < 150 mg/dl and LDL-C < 140 mg/dl; B, TG < 150 mg/dl and LDL-C ≥ 140 mg/dl; C, TG ≥ 150 mg/dl and LDL-C < 140 mg/dl; and D, TG ≥ 150 mg/dl and LDL-C ≥ 140 mg/dl. sd-LDL-C levels and the prevalence of fatty liver were significantly higher in groups B, C, and D than in group A. Subjects were also categorized into four groups based on serum sd-LDL-C levels; the prevalence of fatty liver significantly increased with increasing sd-LDL-C levels. Additionally, logistic regression analysis revealed an independent association between sd-LDL-C concentrations and fatty liver using such potential confounders as obesity and hyperglycemia as variables independent of elevated TG or LDL-C levels. Fatty liver is a significant determinant of serum sd-LDL-C levels independent of the presence of obesity or hyperglycemia. Fatty liver may alter hepatic metabolism of TG and LDL-C, resulting in increased sd-LDL-C levels.
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DOI：
10.1126/science.1168974
发表时间：
2009-07-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Zelcer N;Hong C;Boyadjian R;Tontonoz P
通讯作者：
Tontonoz P
影响因子：
4.4
作者：
Sugino, Ikumi;Kuboki, Koji;Yoshino, Gen
通讯作者：
Yoshino, Gen
影响因子：
15.9
作者：
Ginsberg, HN
通讯作者：
Ginsberg, HN
影响因子：
4.2
作者：
Imamura, Yasushi;Uto, Hirofumi;Tsubouchi, Hirohito
通讯作者：
Tsubouchi, Hirohito
影响因子：
4.4
作者：
Tokuno, Anna;Hirano, Tsutomu;Adachi, Mitsuru
通讯作者：
Adachi, Mitsuru