Exercise and mitochondrial remodeling to prevent age-related neurodegeneration.
Exercise and mitochondrial remodeling to prevent age-related neurodegeneration.
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DOI：
10.1152/japplphysiol.00611.2022
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发表时间：
2023-01-01
影响因子：
3.3
通讯作者：
Lewis Jr, Tommy L.
中科院分区：
文献类型：
--
作者：
O'Reilly, Colleen L.;Miller, Benjamin F.;Lewis Jr, Tommy L.
健康的大脑活动需要精确的离子和能量管理，这就产生了对线粒体功能的强烈依赖。年龄相关的神经退行性变导致线粒体功能下降和氧化应激增加，并伴随线粒体质量、呼吸能力和呼吸效率的下降。线粒体蛋白周转和线粒体动力学相互依赖的过程，被称为线粒体重塑，在线粒体健康和大脑功能中起着至关重要的作用。这篇小型综述描述了线粒体在神经变性和大脑健康中的作用，目前评估线粒体重塑这两个方面的实践，以及运动如何减轻大脑衰老的不利影响。运动训练引发功能适应以改善大脑健康，目前的文献强烈表明，线粒体重塑在这些积极的适应中起着至关重要的作用。尽管线粒体重塑的两个方面是相互依存的，但很少有研究同时测量线粒体动力学和蛋白质合成。更好地了解线粒体蛋白质周转和线粒体动力学之间的伙伴关系，将更好地了解它们在大脑健康和疾病中的作用，以及它们如何在运动后诱导保护。
Healthy brain activity requires precise ion and energy management creating a strong reliance on mitochondrial function. Age-related neurodegeneration leads to a decline in mitochondrial function and increased oxidative stress, with associated declines in mitochondrial mass, respiration capacity, and respiration efficiency. The interdependent processes of mitochondrial protein turnover and mitochondrial dynamics, known together as mitochondrial remodeling, play essential roles in mitochondrial health and therefore brain function. This mini-review describes the role of mitochondria in neurodegeneration and brain health, current practices for assessing both aspects of mitochondrial remodeling, and how exercise mitigates the adverse effects of aging in the brain. Exercise training elicits functional adaptations to improve brain health, and current literature strongly suggests that mitochondrial remodeling plays a vital role in these positive adaptations. Despite substantial implications that the two aspects of mitochondrial remodeling are interdependent, very few investigations have simultaneously measured mitochondrial dynamics and protein synthesis. An improved understanding of the partnership between mitochondrial protein turnover and mitochondrial dynamics will provide a better understanding of their role in both brain health and disease, as well as how they induce protection following exercise.
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作者：
Bo H;Kang W;Jiang N;Wang X;Zhang Y;Ji LL
通讯作者：
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DOI：
10.1083/jcb.201401070
发表时间：
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期刊：
The Journal of cell biology
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DOI：
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发表时间：
2003-01-20
期刊：
The Journal of cell biology
影响因子：
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通讯作者：
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