PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.

PepCyber:P~PEP: a database of human protein protein interactions mediated by phosphoprotein-binding domains.
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Pepcyber:P〜PEP:由磷蛋白结合结构域介导的人类蛋白质相互作用的数据库。

DOI:
10.1093/nar/gkm854
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发表时间:
2008-01
影响因子:
14.9
通讯作者:
Li, Tongbin
Li, Tongbin
中科院分区:
生物学2区
文献类型:
--
作者:
Gong, Wuming;Zhou, Dihan;Ren, Yongliang;Wang, Yejun;Zuo, Zhixiang;Shen, Yanping;Xiao, Feifei;Zhu, Qi;Hong, Ailing;Zhou, Xiaochuan;Gao, Xiaolian;Li, Tongbin

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磷蛋白结合域(PPBD)介导许多重要的细胞和分子过程。已知在人类蛋白质组中存在10个PPBD,即14-3-3、BRCT、C2、FHA、MH 2、PBD、PTB、SH 2、WD-40和WW。PepCyber:PepCyber PEP是一个新构建的数据库,专门记录人类含PPBD的蛋白质和PPBD介导的相互作用。我们的动机是为研究界提供丰富的信息来源,强调特定PPBD-PPEP相互作用的报告,实验验证的数据。这些信息不仅对于设计、比较和验证相关实验有用,而且还可以作为计算构建系统信号通路和网络的知识库。PepCyber:可通过URL http://www.pepcyber.org/PPEP/访问 PepCyber。目前发布的数据库包含7044个PPBD介导的相互作用,涉及337个含PPBD的蛋白质和1123个底物蛋白质。
Phosphoprotein-binding domains (PPBDs) mediate many important cellular and molecular processes. Ten PPBDs have been known to exist in the human proteome, namely, 14-3-3, BRCT, C2, FHA, MH2, PBD, PTB, SH2, WD-40 and WW. PepCyber:P∼PEP is a newly constructed database specialized in documenting human PPBD-containing proteins and PPBD-mediated interactions. Our motivation is to provide the research community with a rich information source emphasizing the reported, experimentally validated data for specific PPBD–PPEP interactions. This information is not only useful for designing, comparing and validating the relevant experiments, but it also serves as a knowledge-base for computationally constructing systems signaling pathways and networks. PepCyber:P∼PEP is accessible through the URL, http://www.pepcyber.org/PPEP/. The current release of the database contains 7044 PPBD-mediated interactions involving 337 PPBD-containing proteins and 1123 substrate proteins.
DOI: 10.1093/nar/gkg584
发表时间: 2003-07-01
影响因子: 14.9
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