Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses.
Simultaneous Tumor and Stroma Targeting by Oncolytic Viruses.
复制标题
溶瘤病毒同时靶向肿瘤和基质。
DOI：
10.3390/biomedicines8110474
复制
发表时间：
2020-11-05
期刊：
影响因子：
4.7
通讯作者：
Kemp V
中科院分区：
文献类型：
--
作者：
Everts A;Bergeman M;McFadden G;Kemp V
由于周围致密的肿瘤基质，目前的癌症治疗剂通常不足以根除恶性细胞。这种多组分组织主要由癌症相关的成纤维细胞、（致密的）细胞外基质、肿瘤脉管系统和肿瘤相关的巨噬细胞组成，它们都在维持促肿瘤生态位中发挥关键作用。它们与肿瘤细胞持续复杂的相互作用促进肿瘤进展和转移，突出了肿瘤治疗发展的挑战。在过去的十年中，溶瘤病毒治疗的进展已经表明，溶瘤病毒（OV）是一个有前途的多方面的治疗平台，同时肿瘤和基质靶向。除了促进肿瘤细胞溶瘤和全身抗肿瘤免疫外，积累的数据表明OV还可以直接靶向基质组分，促进OV复制和扩散，以及促进抗肿瘤活性。本综述提供了一个全面的概述之间的相互作用的天然和基因修饰的OVs和不同的靶向肿瘤间质成分，并概述了战略，以提高基质靶向OVs。
Current cancer therapeutics often insufficiently eradicate malignant cells due to the surrounding dense tumor stroma. This multi-componential tissue consists of mainly cancer-associated fibroblasts, the (compact) extracellular matrix, tumor vasculature, and tumor-associated macrophages, which all exert crucial roles in maintaining a pro-tumoral niche. Their continuous complex interactions with tumor cells promote tumor progression and metastasis, emphasizing the challenges in tumor therapy development. Over the last decade, advances in oncolytic virotherapy have shown that oncolytic viruses (OVs) are a promising multi-faceted therapeutic platform for simultaneous tumor and stroma targeting. In addition to promoting tumor cell oncolysis and systemic anti-tumor immunity, accumulating data suggest that OVs can also directly target stromal components, facilitating OV replication and spread, as well as promoting anti-tumor activity. This review provides a comprehensive overview of the interactions between native and genetically modified OVs and the different targetable tumor stromal components, and outlines strategies to improve stroma targeting by OVs.
登录
查看更多内容
影响因子：
5.2
作者：
Eissa IR;Bustos-Villalobos I;Ichinose T;Matsumura S;Naoe Y;Miyajima N;Morimoto D;Mukoyama N;Zhiwen W;Tanaka M;Hasegawa H;Sumigama S;Aleksic B;Kodera Y;Kasuya H
通讯作者：
Kasuya H
影响因子：
11.2
作者：
Aghi, Manish;Rabkin, Samuel D.;Martuza, Robert L.
通讯作者：
Martuza, Robert L.
影响因子：
28.2
作者：
Elyada, Ela;Bolisetty, Mohan;Tuveson, David A.
通讯作者：
Tuveson, David A.
特定癌症类型的长期和潜在副作用。
DOI：
10.1016/j.mcna.2017.06.003
发表时间：
2017-11
期刊：
The Medical clinics of North America
影响因子：
--
作者：
Gegechkori N;Haines L;Lin JJ
通讯作者：
Lin JJ
影响因子：
3.8
作者：
Bartee, Eric;McFadden, Grant
通讯作者：
McFadden, Grant