Human leucocyte antigen Class I and II alleles associated with anti-hepatitis C virus-positive patients of North India
Human leucocyte antigen Class I and II alleles associated with anti-hepatitis C virus-positive patients of North India
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人类白细胞抗原 I 类和 II 类等位基因与印度北部抗丙型肝炎病毒阳性患者相关
DOI：
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发表时间：
2016
影响因子：
1.6
通讯作者：
Y. Thakur
中科院分区：
文献类型：
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作者：
M. Chowdhry;R. Makroo;M. Singh;S. Agrawal;M. Kumar;Y. Thakur
目的：人类是丙型肝炎病毒（HCV）唯一已知的自然宿主。本研究旨在检测印度北方抗HCV感染患者中人类白细胞抗原（HLA）I类和II类基因型分布的频率。材料与方法：从2013年1月至2014年8月，148名来自印度北部的抗HCV阳性患者被转诊至新德里Indraprastha Apollo医院分子生物学和移植免疫学部门进行HLA分型。结果：抗-HCV阳性患者AFNx 0102、AFNx 0131等位基因频率明显降低。HLA-B位点的频率没有达到任何统计学意义。在II类等位基因中，与对照组相比，患者群体中HLA-DRB 1FNx 0103和HLA-DRB 1FNx 0110显著较高，而患者群体中HLA-DRB 1FNx 0115显著降低。结论：HLA-AFNx 0133与对照人群相比显著增加，并且在印度HCV感染个体中显示出地理变异。
Purpose: Humans are the only known natural hosts of hepatitis C virus (HCV). This study was undertaken to examine the frequencies of human leucocyte antigens (HLAs) Class I and Class II genotype profiles in anti-HCV-infected patients of Northern India. Materials and Methods: From a period of January 2013 to August 2014, 148 anti-HCV-positive patients of North India referred to the Department of Molecular Biology and Transplant Immunology, Indraprastha Apollo Hospitals, New Delhi, for performing HLA typing were included in the study. Results: AFNx0102, AFNx0131 allele frequency decreased significantly in anti-HCV-positive patients. Frequencies for HLA-B loci did not reach any statistical significance. Among the Class II alleles, HLA-DRB1FNx0103 and HLA-DRB1FNx0110 were significantly higher in the patient population, and HLA-DRB1FNx0115 was significantly decreased in the patient population as compared to the controls. Conclusion: HLA-AFNx0133 was significantly increased as compared to control population and showed geographic variation in HCV-infected individuals of India.
影响因子：
6.4
作者：
Thio, CL;Carrington, M;Thomas, DL
通讯作者：
Thomas, DL