CD98 heavy chain as a prognostic biomarker and target for cancer treatment.
CD98 heavy chain as a prognostic biomarker and target for cancer treatment.
复制标题
DOI：
10.3389/fonc.2023.1251100
复制
发表时间：
2023
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
SLC3A2基因编码细胞表面跨膜蛋白CD98hc（4F2）。CD98hc作为LAT1（SLC7A5）、LAT2（SLC7A8）、y+LAT1（SLC7A7）、y+LAT2（SLC7A6）、xCT（SLC7A11）和Asc1（SLC7A10）的伴侣蛋白，将它们募集到质膜。它与轻亚基一起构成异二聚体跨膜氨基酸转运蛋白。CD98hc与其他表面分子相互作用，如细胞外基质金属蛋白酶诱导剂CD147（EMMPRIN）和粘附受体整合素，并调节葡萄糖摄取。通过这种方式，CD98hc连接维持细胞增殖和迁移、生物合成和抗氧化防御、能量产生和干细胞特性的信号传导途径。这种多方面的作用使CD98hc成为肿瘤生长、治疗抗性和转移的关键调节因子之一。实际上，在各种肿瘤组织中证实了CD98hc的高表达水平，包括头颈部鳞状细胞癌、胶质母细胞瘤、结肠腺癌、胰腺导管腺癌等。在几种类型的癌症中，CD98hc的高表达与临床预后以及对化疗和放疗的反应有关。本文就CD98 hc的生理功能、在肿瘤干细胞、转移和耐药中的作用以及作为肿瘤标志物和治疗靶点的临床意义进行综述。
The SLC3A2 gene encodes for a cell-surface transmembrane protein CD98hc (4F2). CD98hc serves as a chaperone for LAT1 (SLC7A5), LAT2 (SLC7A8), y+LAT1 (SLC7A7), y+LAT2 (SLC7A6), xCT (SLC7A11) and Asc1 (SLC7A10) providing their recruitment to the plasma membrane. Together with the light subunits, it constitutes heterodimeric transmembrane amino acid transporters. CD98hc interacts with other surface molecules, such as extracellular matrix metalloproteinase inducer CD147 (EMMPRIN) and adhesion receptors integrins, and regulates glucose uptake. In this way, CD98hc connects the signaling pathways sustaining cell proliferation and migration, biosynthesis and antioxidant defense, energy production, and stem cell properties. This multifaceted role makes CD98hc one of the critical regulators of tumor growth, therapy resistance, and metastases. Indeed, the high expression levels of CD98hc were confirmed in various tumor tissues, including head and neck squamous cell carcinoma, glioblastoma, colon adenocarcinoma, pancreatic ductal adenocarcinoma, and others. A high expression of CD98hc has been linked to clinical prognosis and response to chemo- and radiotherapy in several types of cancer. In this mini-review, we discuss the physiological functions of CD98hc, its role in regulating tumor stemness, metastases, and therapy resistance, and the clinical significance of CD98hc as a tumor marker and therapeutic target.
登录
查看更多内容
影响因子：
4.6
作者：
Console, Lara;Scalise, Mariafrancesca;Salerno, Simona;Scanga, Raffaella;Giudice, Deborah;De Bartolo, Loredana;Tonazzi, Annamaria;Indiveri, Cesare
通讯作者：
Indiveri, Cesare
影响因子：
5.6
作者：
通讯作者：
--
影响因子：
2.7
作者：
Tsumura H;Ito M;Takami M;Arai M;Li XK;Hamatani T;Igarashi A;Takada S;Miyado K;Umezawa A;Ito Y
通讯作者：
Ito Y
DOI：
10.1126/science.aaw9872
发表时间：
2020-04-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Badgley MA;Kremer DM;Maurer HC;DelGiorno KE;Lee HJ;Purohit V;Sagalovskiy IR;Ma A;Kapilian J;Firl CEM;Decker AR;Sastra SA;Palermo CF;Andrade LR;Sajjakulnukit P;Zhang L;Tolstyka ZP;Hirschhorn T;Lamb C;Liu T;Gu W;Seeley ES;Stone E;Georgiou G;Manor U;Iuga A;Wahl GM;Stockwell BR;Lyssiotis CA;Olive KP
通讯作者：
Olive KP
影响因子：
50.3
作者：
Bajaj J;Konuma T;Lytle NK;Kwon HY;Ablack JN;Cantor JM;Rizzieri D;Chuah C;Oehler VG;Broome EH;Ball ED;van der Horst EH;Ginsberg MH;Reya T
通讯作者：
Reya T