COVID-19 and Risk of Acute Ischemic Stroke and Acute Lung Injury in Patients With Type II Diabetes Mellitus: The Anti-inflammatory Role of Metformin.
COVID-19 and Risk of Acute Ischemic Stroke and Acute Lung Injury in Patients With Type II Diabetes Mellitus: The Anti-inflammatory Role of Metformin.
复制标题
COVID-19与II型糖尿病患者急性缺血性卒中和急性肺损伤的风险：二甲双胍的抗炎作用。
DOI：
10.3389/fmed.2021.644295
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Batiha GE
中科院分区：
文献类型：
--
作者：
Al-Kuraishy HM;Al-Gareeb AI;Alblihed M;Cruz-Martins N;Batiha GE
背景：冠状病毒病 19（COVID-19）由于诱导内皮功能障碍、凝血病、细胞因子风暴和斑块不稳定而被认为是急性缺血性卒中（AIS）的独立危险因素。方法：在这项回顾性队列研究中，共招募了 42 名患有 2 型糖尿病 (T2DM) 的 COVID-19 患者，这些患者在出现 COVID-19 症状后 1 周内出现 AIS。根据目前的抗DM药物治疗，将患者分为两组：二甲双胍组，即患有COVID-19和AIS的T2DM患者，接受二甲双胍治疗（850 mg，每日3次）（n = 22）；非二甲双胍组，即患有COVID-19和AIS的T2DM患者，接受另一种抗DM药物治疗，如格列本脲和吡格列酮（n = 20）。结果：与未接受二甲双胍治疗的患者相比，接受二甲双胍治疗的患者的铁蛋白血清水平较低（365.93 ± 17.41 vs. 475.92 ± 22.78 ng/mL，p = 0.0001）。此外，二甲双胍治疗的 COVID-19 患者的肺部 CT 扫描评分为 30.62 ± 10.64，未接受二甲双胍治疗的患者的肺部 CT 扫描评分为 36.31 ± 5.03。 结论：二甲双胍治疗与 COVID-19 期间 AIS 风险降低有关，需要进一步研究观察 COVID-19 糖尿病患者的 AIS 与二甲双胍治疗之间的联系。
Background: Coronavirus disease 19 (COVID-19) is regarded as an independent risk factor for acute ischemic stroke (AIS) due to the induction of endothelial dysfunction, coagulopathy, cytokine storm, and plaque instability. Method: In this retrospective cohort study, a total of 42 COVID-19 patients with type 2 diabetes mellitus (T2DM) who presented with AIS within 1 week of displaying COVID-19 symptoms were recruited. According to the current anti-DM pharmacotherapy, patients were divided into two groups: a Metformin group of T2DM patients with COVID-19 and AIS on metformin therapy (850 mg, 3 times daily (n = 22), and a Non-metformin group of T2DM patients with COVID-19 and AIS under another anti-DM pharmacotherapy like glibenclamide and pioglitazone (n = 20). Anthropometric, biochemical, and radiological data were evaluated. Results: Ferritin serum level was lower in metformin-treated patients compared to non-metformin treated patients (365.93 ± 17.41 vs. 475.92 ± 22.78 ng/mL, p = 0.0001). CRP, LDH, and D-dimer serum levels were also lowered in metformin-treated patients compared to non-metformin treated patients (p = 0.0001). In addition, lung CT scan scores of COVID-19 patients was 30.62 ± 10.64 for metformin and 36.31 ± 5.03 for non-metformin treated patients. Conclusion: Metformin therapy in T2DM patients was linked to a lower risk of AIS during COVID-19. Further studies are needed to observe the link between AIS in COVID-19 diabetic patients and metformin therapy.
登录
查看更多内容
影响因子：
28.2
作者：
Liu, Yuwei;Du, Xuebei;Zhao, Yan
通讯作者：
Zhao, Yan
影响因子：
1.4
作者：
Al-Kuraishy, Hayder M.;Al-Gareeb, Ali, I;Naji, Marwa Thaier
通讯作者：
Naji, Marwa Thaier
二甲双胍可减轻小鼠大脑中动脉闭塞后血脑屏障的破坏
影响因子：
9.3
作者：
Liu Y;Tang G;Li Y;Wang Y;Chen X;Gu X;Zhang Z;Wang Y;Yang GY
通讯作者：
Yang GY
DOI：
10.5455/jice.20160815080732
发表时间：
2016-09
期刊：
Journal of intercultural ethnopharmacology
影响因子：
--
作者：
Al-Kuraishy HM;Al-Gareeb AI
通讯作者：
Al-Gareeb AI
DOI：
10.1016/j.jstrokecerebrovasdis.2015.10.016
发表时间：
2016-02-01
影响因子：
2.5
作者：
Mima, Yohei;Kuwashiro, Takahiro;Okada, Yasushi
通讯作者：
Okada, Yasushi