Roles of ten-eleven translocation family proteins and their O-linked β-N-acetylglucosaminylated forms in cancer development.
Roles of ten-eleven translocation family proteins and their O-linked β-N-acetylglucosaminylated forms in cancer development.
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十十一易位家族蛋白及其 O 连接 β-N-乙酰氨基葡萄糖化形式在癌症发展中的作用
DOI：
10.3892/ol.2020.12262
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发表时间：
2021-01
期刊：
影响因子：
2.9
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Li HJ;Wang Y;Li BX;Yang Y;Guan F;Pang XC;Li X
10 - 11易位（TET）蛋白家族的成员，其中迄今已发现3个哺乳动物TET蛋白，催化5-甲基胞嘧啶依次氧化为5-羟甲基胞嘧啶、5-甲酰胞嘧啶和5-羧基胞嘧啶，在胚胎发育和肿瘤进展中起重要作用。o - glcnac酰化（O-linked β-N-acetylglucosaminylation, O-linked β-N-acetylglucosaminylation）是一种可逆的翻译后修饰，在肿瘤发生和转移中起重要作用，特别是在造血恶性肿瘤如骨髓增生异常综合征、慢性髓细胞白血病和急性髓细胞白血病中。o - glcn酰化活性只需要两种酶：O-GlcNAc转移酶（OGT）和O-GlcNAcase （OGA）。OGT催化GlcNAc糖附着在蛋白质中的丝氨酸、苏氨酸和胞嘧啶残基上，而OGA水解附着在蛋白质上的O-GlcNAc。最近的许多研究表明，TET可以被OGT乙酰化，从而改变TET的活性和稳定性。本文综述了TET及其o - glcn酰化形式的细胞、生物学和生化功能，并提出了TET/OGT复合物在癌症发展过程中调控靶蛋白的作用模型。此外，本文还为今后的研究提供了方向。
Members of the ten-eleven translocation (TET) protein family of which three mammalian TET proteins have been discovered so far, catalyze the sequential oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine which serve an important role in embryonic development and tumor progression. O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is a reversible post-translational modification known to serve important roles in tumorigenesis and metastasis especially in hematopoietic malignancies such as myelodysplastic syndromes, chronic myelomonocytic leukemia and acute myeloid leukemia. O-GlcNAcylation activity requires only two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). OGT catalyzes attachment of GlcNAc sugar to serine, threonine and cytosine residues in proteins, while OGA hydrolyzes O-GlcNAc attached to proteins. Numerous recent studies have demonstrated that TETs can be O-GlcNAcylated by OGT, with consequent alteration of TET activity and stability. The present review focuses on the cellular, biological and biochemical functions of TET and its O-GlcNAcylated form and proposes a model of the role of TET/OGT complex in regulation of target proteins during cancer development. In addition, the present review provides directions for future research in this area.
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影响因子：
11.4
作者：
通讯作者：
--
DOI：
10.1002/ajmg.b.32567
发表时间：
2017-09
期刊：
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
影响因子：
--
作者：
Alam R;Abdolmaleky HM;Zhou JR
通讯作者：
Zhou JR
DOI：
10.1074/jbc.m114.605881
发表时间：
2015-02-20
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Bauer C;Göbel K;Nagaraj N;Colantuoni C;Wang M;Müller U;Kremmer E;Rottach A;Leonhardt H
通讯作者：
Leonhardt H
DOI：
10.1073/pnas.1805397115
发表时间：
2018-11-20
影响因子：
11.1
作者：
Berthier A;Vinod M;Porez G;Steenackers A;Alexandre J;Yamakawa N;Gheeraert C;Ploton M;Maréchal X;Dubois-Chevalier J;Hovasse A;Schaeffer-Reiss C;Cianférani S;Rolando C;Bray F;Duez H;Eeckhoute J;Lefebvre T;Staels B;Lefebvre P
通讯作者：
Lefebvre P
影响因子：
14.9
作者：
Good CR;Madzo J;Patel B;Maegawa S;Engel N;Jelinek J;Issa JJ
通讯作者：
Issa JJ