Microbiome, inflammation, epigenetic alterations, and mental diseases.
Microbiome, inflammation, epigenetic alterations, and mental diseases.
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DOI：
10.1002/ajmg.b.32567
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Zhou JR
中科院分区：
文献类型：
--
作者：
Alam R;Abdolmaleky HM;Zhou JR
严重的精神疾病，如自闭症、躁郁症、精神分裂症和严重抑郁症，都是具有复杂病因的衰弱性疾病。最近的研究结果表明，这些疾病的发生和发展不能很好地描述了一个基因;一种疾病的方法。相反，它们的临床表现被认为是由大量基因的调节相互作用引起的。尽管可能涉及许多基因，但环境因素对这些基因的上调和激活或下调和沉默在其发病机制中起着至关重要的作用。这种相互作用可能会受到表观遗传变化的调节。与基因突变类似，表观遗传修饰（如DNA甲基化、组蛋白修饰和RNA干扰）可以影响基因表达，因此可能导致在精神障碍中观察到的行为和神经元变化。环境因素如饮食、肠道微生物群和感染在这些表观遗传修饰中起着重要作用。研究表明，生物活性营养素和肠道微生物群可以通过多种机制改变DNA甲基化和组蛋白特征。事实上，人类肠道内的微生物可能在调节“肠-脑轴”的各种要素中发挥重要作用，这是通过它们对炎性细胞因子的影响以及通过它们参与产生短链脂肪酸、维生素合成和营养吸收而影响表观基因组的抗微生物肽的产生来实现的。此外，它们可能参与肠道中许多常见神经递质的产生。在这篇综述中，我们将考虑饮食，胃肠道微生物组，炎症和精神疾病的表观遗传改变的潜在相互作用。
Major mental diseases such as autism, bipolar disorder, schizophrenia, and major depressive disorder are debilitating illnesses with complex etiologies. Recent findings show that the onset and development of these illnesses cannot be well described by the one-gene; one-disease approach. Instead, their clinical presentation is thought to result from the regulative interplay of a large number of genes. Even though the involvement of many genes are likely, up regulating and activation or down regulation and silencing of these genes by the environmental factors play a crucial role in contributing to their pathogenesis. Much of this interplay may be moderated by epigenetic changes. Similar to genetic mutations, epigenetic modifications such as DNA methylation, histone modifications, and RNA interference can influence gene expression and therefore may cause behavioral and neuronal changes observed in mental disorders. Environmental factors such as diet, gut microbiota, and infections have significant role in these epigenetic modifications. Studies show that bioactive nutrients and gut microbiota can alter either DNA methylation and histone signatures through a variety of mechanisms. Indeed, microbes within the human gut may play a significant role in the regulation of various elements of “gut-brain axis,” via their influence on inflammatory cytokines and production of antimicrobial peptides that affect the epigenome through their involvement in generating short chain fatty acids, vitamin synthesis, and nutrient absorption. In addition, they may participate in-gut production of many common neurotransmitters. In this review we will consider the potential interactions of diet, gastrointestinal microbiome, inflammation, and epigenetic alterations in psychiatric disorders.
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影响因子：
5
作者：
D'Argenio, Valeria;Salvatore, Francesco
通讯作者：
Salvatore, Francesco
DOI：
10.1016/b978-0-12-417114-5.00011-5
发表时间：
2014-01-01
期刊：
EPIGENETICS IN PSYCHIATRY
影响因子：
--
作者：
Abdolmaleky, Hamid Mostafavi;Thiagalingam, Sam
通讯作者：
Thiagalingam, Sam
影响因子：
11
作者：
Fernandes, B. S.;Steiner, J.;Berk, M.
通讯作者：
Berk, M.
多发性硬化症和精神分裂症之间的遗传多效性，但不是躁郁症：免疫相关基因基因座的差异参与。
影响因子：
11
作者：
Andreassen, O. A.;Harbo, H. F.;Wang, Y.;Thompson, W. K.;Schork, A. J.;Mattingsdal, M.;Zuber, V.;Bettella, F.;Ripke, S.;Kelsoe, J. R.;Kendler, K. S.;O'Donovan, M. C.;Sklar, P.;McEvoy, L. K.;Desikan, R. S.;Lie, B. A.;Djurovic, S.;Dale, A. M.
通讯作者：
Dale, A. M.
影响因子：
6.8
作者：
Beydoun, M. A.;Beydoun, H. A.;Zonderman, A. B.
通讯作者：
Zonderman, A. B.