Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia.
Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia.
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DOI：
10.1016/j.semarthrit.2018.09.001
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发表时间：
2019-06
影响因子：
5
通讯作者：
Grayson PC
中科院分区：
文献类型：
--
作者：
Banerjee S;Bagheri M;Sandfort V;Ahlman MA;Malayeri AA;Bluemke DA;Yao J;Grayson PC
冠状动脉、主动脉和分支血管钙化可发生在大血管炎（LVV）和动脉粥样硬化中。该研究的目的是确定LVV与高脂血症（HLD）患者血管钙化的位置和数量，并确定与LVV血管钙化相关的危险因素。巨细胞动脉炎（GCA）， Takayasu动脉炎（TAK）和HLD患者接受主动脉和分支血管的非对比计算机断层扫描。通过累积Agatston评分量化整个大动脉的14个特定动脉区域（主动脉4段，9支动脉和冠状动脉）的血管钙化。多变量线性回归分析用于确定传统和疾病特异性危险因素与Agatston总分之间的关联。共88名受试者，包括GCA (n=29)；达克(n = 22);HLD （n=37）参与。冠状动脉主动脉和分支血管钙化率差异有统计学意义（HLD=67%， GCA=35%， TAK=9%, p<0.01）。GCA的Agatston总分（中位数3260，范围25-18138）高于HLD (460, 19-17215) (p<0.01)，但GCA和TAK（1944, 52-47520）之间无显著差异（p=0.53）。在多变量回归分析中，年龄、血管炎类型和强的松使用与左室血管钙化有关。与HLD相比，LVV的冠状动脉钙化发生率较低，但整个大动脉的血管钙化总量在LVV中更大。传统的和疾病特异性的危险因素都与左室血管钙化有关。
Calcification of the coronary arteries, aorta, and branch vessels can occur in both large-vessel vasculitis (LVV) and atherosclerosis. The study objective was to determine the location and amount of vascular calcification in patients with LVV versus hyperlipidemia (HLD) and to identify risk factors associated with vascular calcification in LVV. Patients with giant cell arteritis (GCA), Takayasu’s arteritis (TAK), and HLD underwent non-contrast computed tomography of the aorta and branch vessels. Vascular calcification in 14 specific arterial territories (4 segments of the aorta, 9 branch arteries, and the coronary arteries) was quantified throughout the large arteries by a cumulative Agatston score. Multivariate linear regression analyses were used to identify associations between traditional and disease-specific risk factors and total Agatston score. A total of 88 subjects, including GCA (n=29); TAK (n=22); and HLD (n=37), participated.Prevalence of vascular calcification in the aorta and branch vessels significantly differed in the coronary arteries (HLD=67%, GCA=35%, TAK=9%, p<0.01). Total Agatston scores were higher in GCA (median 3260, range 25-18138) versus HLD (460, 19-17215) (p<0.01) but did not significantly differ between GCA and TAK (1944, 52-47520) (p=0.53). In multivariable regression analysis, age, type of vasculitis, and prednisone use was associated with vascular calcification in LVV. The prevalence of coronary artery calcification is lower in LVV compared to HLD, but the amount of total vascular calcification throughout the large arteries is greater in LVV. Both traditional and disease-specific risk factors are associated with vascular calcification in LVV.
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影响因子：
2.1
作者：
Barra, Lillian;Liang, Patrick;Pagnoux, Christian
通讯作者：
Pagnoux, Christian
DOI：
10.1177/153857447300700501
发表时间：
1973-01-01
期刊：
VASCULAR SURGERY
影响因子：
--
作者：
LUPIH, E;HORWITZ, S;SANCHEZT, G
通讯作者：
SANCHEZT, G
影响因子：
1.5
作者：
Nishiyama, A;Matsubara, S;Toyama, J
通讯作者：
Toyama, J
影响因子：
16.2
作者：
Reaven, PD;Sacks, J
通讯作者：
Sacks, J
影响因子：
4.8
作者：
Alexopoulos, D;Toulgaridis, T;Vagenakis, AG
通讯作者：
Vagenakis, AG